ArticleOpen veterinary journal2025
Luteal insufficiency in canines: Assessment of progesterone dynamics and efficacy of combined hormonal treatment.
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Mid-gestational luteal insufficiency in predisposed dog breeds: Retrospective evaluation of medroxyprogesterone acetate therapy and timed-withdrawal.Veterinary world · 2026Article
- Immunometabolic-uterine-ovarian interactions and flushing therapy in dairy cows: a narrative review.Veterinary world · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Progesterone, primarily produced by the corpus luteum, is essential for maintaining pregnancy in dogs by promoting endometrial receptivity and supporting fetal development. Hypoluteoidism, defined as inadequate progesterone production, significantly increases the risk of pregnancy loss and reproductive failure. This study evaluated the role of progesterone in canine pregnancy, the risks associated with hormonal deficiency, and the effectiveness of therapeutic interventions. Aim: This study emphasized the role of progesterone supplementation combined with magnesium and tocopherol in supporting pregnancy maintenance and restoring hormonal homeostasis. Methods: Progesterone levels were monitored across the estrous cycle in French Bulldog bitches ( Results: During the anestrus phase (control group C1), the progesterone concentration was minimal (1.53 ± 0.07 nmol/l). Progesterone levels showed significant variation across different phases of the estrous cycle, measuring 4.56 ± 0.20 nmol/l ( Conclusion: Progesterone therapy, when combined with tocopherol and magnesium, effectively addresses luteal insufficiency in dogs, improving implantation success rates and reducing pregnancy loss. This study highlights the importance of progesterone in canine reproduction and supports its supplementation as a viable treatment for hormonal imbalance.
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Registered trials
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