Evidence map›Paper›PMID 40989631›Full record

ReviewOpen veterinary journal2025

Phytochemical profiling and biological activity of the ethanolic extract of

Sarah A Abdulla, Farag A Elshaari, Mohamed Alshintari, Lazhar Zourgui

Abstract readReview
In one paragraph

Review in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sarah A AbdullaFaculty of Science of Bizerte, University of Carthage, Jarzouna, Tunisia.
Farag A ElshaariDepartment of Biochemistry, Faculty of Medicine, University of Benghazi, Benghazi, Libya.
Mohamed AlshintariLibya Center for Biotechnology Research, Tripoli, Libya.
Lazhar ZourguiResearch Laboratory BMA "Biodiversity, Molecules, Application" Higher Institute of Applied Biology of Medenine, University of Gabes, Medenine, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Phragmites australis, a grass species of the Poaceae family, was studied here for the first time in Libya, marking its initial documented phytochemical and biological evaluation. In traditional folk medicine, P. australis has a promising therapeutic potential. Aim: This study analyzed and identified phytochemical compounds and the antioxidant, cytotoxic, antimicrobial, and antiviral activities of Methods: Phytochemical profiling was conducted using liquid chromatography-mass spectrometry. Antioxidant properties were evaluated using ferric reducing antioxidant power, 2,2-diphenyl-1-picrylhydrazyl, nitric oxide, total antioxidant capacity, and Trolox equivalent antioxidant capacity assays. The cytotoxic effects of the extracts on the breast (MCF-7), hepatocellular (Hep-G2), and colon (Caco-2) cancer cell lines were assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Antimicrobial effects were tested against four bacterial strains and three fungi, and the antiviral activities of the extracts against herpes simplex virus type 1 (HSV-1) and hepatitis A virus (HAV) were assessed. Results: The PAEE contained 65.94 mg/gallic acid equivalents g of total phenolics and 22.7 mg/RE g of total flavonoids. Phytochemical analysis revealed the presence of key bioactive compounds, including flavonoids such as rutin, quercetin, luteolin-7-O-glucoside, caffeic acid, and apigenin-6-C-glucoside, as well as phenolic acids, such as protocatechuic acid, coumaric acid, and feruloyl-quinic acid derivatives.The extract exhibited significant antioxidant activity. Additionally, the extract exhibited potent antimicrobial efficacy, particularly in counteracting Conclusion: This study is the first to investigate

Indexed as

Anti-Infective AgentsAntioxidantsAntiviral AgentsPhytochemicalsPlant ExtractsPoaceaeCell Line, TumorHumansAnti-Infective AgentsAntioxidantsAntiviral AgentsPhytochemicalsPlant ExtractsAntioxidant activityAntiviral activityLC–MS analysisPhenolicsPhragmites australis

Identifiers

PMID40989631
PMCPMC12451134

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.