Development of a green spectrofluorimetric method for mefenamic acid determination using Rhodamine 6G with mechanistic investigation and central composite design optimization.

Arwa Sultan Alqahtani, Maram H Abduljabbar, Reem M Alnemari, Saleh I Alaqel, Ahmed Serag, Atiah H Almalki

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Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Arwa Sultan AlqahtaniDepartment of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU) P.O. Box 90950 Riyadh 11623 Saudi Arabia.

Maram H AbduljabbarDepartment of Pharmacology and Toxicology, College of Pharmacy, Taif University P.O. Box 11099 Taif 21944 Saudi Arabia.

Reem M AlnemariDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University P.O. Box 11099 Taif 21944 Saudi Arabia.

Saleh I AlaqelDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University Rafha 91911 Saudi Arabia.

Ahmed SeragPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University Nasr City Cairo 11751 Egypt Ahmedserag777@hotmail.com.ORCID https://orcid.org/0000-0003-1559-8079

Atiah H AlmalkiAddiction and Neuroscience Research Unit, Health Science Campus, Taif University P.O. Box 11099 Taif 21944 Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spectrofluorimetry has emerged as a powerful analytical technique offering high sensitivity, selectivity, and environmental compatibility for pharmaceutical analysis. This study aims to develop a novel fluorescence quenching method for mefenamic acid determination using Rhodamine 6G as a molecular probe. Comprehensive spectral characterization revealed that Rhodamine 6G exhibits characteristic absorption at 530 nm and emission at 555 nm, with systematic fluorescence quenching upon mefenamic acid addition while preserving the emission spectral profile. Mechanistic investigation through Stern-Volmer analysis, thermodynamic studies, and Job's method established static quenching

Identifiers

PMID40989526

DOI10.1039/d5ra05667e

PMCPMC12451673

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