ArticleFrontiers in cellular and infection microbiology2025
Assessment of a rapid diagnostic test based on loop-mediated isothermal amplification (LAMP) to identify the most frequent pathogens causing hospital-acquired pneumonia.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Environmental Application of Newly Designed Loop-Mediated Isothermal Amplification (LAMP) Kits for Nosocomial Pathogen Detection in Hospital Settings.Life (Basel, Switzerland) · 2026Article
- Evolving Approaches to Bacterial Identification: A Review of Classical and Modern Techniques.International journal of molecular sciences · 2026Review
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9 authors.
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Abstract
Introduction: Hospital-acquired pneumonia (HAP) is a serious infection affecting patients in the hospital setting. This study aimed to evaluate a novel multiplex detection method using loop-mediated isothermal amplification (LAMP) technology to identify six primary bacterial pathogens responsible for HAP directly from respiratory samples. Methods: A total of 119 clinical samples were analyzed by LAMP technology, including mainly bronchoalveolar lavages, endotracheal aspirates, and bronchoaspirates. Results and discussion: The results of the LAMP and traditional culture methods showed an accuracy of 93.0%. In some discordant cases between culture and LAMP, multiplex PCR (FilmArray Pneumonia Panel) showed a strong correlation with the LAMP results, confirming the potential use of this technique as a diagnostic detection tool. The clinical sensitivity of the LAMP assay was 93.3% with a specificity of 92.0%. Correlation analysis revealed a weak negative relationship between bacterial load and time to positivity (
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