ArticleFrontiers in cellular and infection microbiology2025
Curcumin-photosensitized nanocapsules: biocompatibility and antimicrobial evaluation in primary tooth dentin contaminated with
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Recent Advances in Caries Prevention and Non-Invasive Management: From Ecological Modulation to Precision Interventions.Dentistry journal · 2026Review
- Photodynamic therapy for caries management: mechanisms, applications, and perspectives.Frontiers in cellular and infection microbiology · 2026Review
- New Technologies and Materials in Oral Health and Dental Care of Pediatric Dentistry.Children (Basel, Switzerland) · 2025Article
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Authors and funding
11 authors.
Funding
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Abstract
Introduction: Dental caries is a multifactorial disease with high prevalence, particularly in vulnerable populations, where Methods: Zein-based nanocapsules loaded with curcumin (Nano-curcumin) were synthesized via nanoprecipitation and characterized for encapsulation efficiency, particle size, polydispersity, zeta potential, morphology, and curcumin release. Biocompatibility was assessed using rabbit oral mucosal cells via MTT and trypan blue assays. Antimicrobial efficacy was tested in vitro on primary dentin slices contaminated with S. mutans across four groups: Nano-curcumin, Nano-curcumin + PDT, diode laser, and untreated control. Colony-forming units (CFU) were quantified after treatment. Statistical analysis was performed using ANOVA and Tukey's test (p < 0.05). Results: Nano-curcumin demonstrated high encapsulation efficiency (~100%), spherical morphology, low polydispersity (0.108), and favorable colloidal stability, with sustained curcumin release over 24 hours. Cytotoxicity assays showed >50% cell viability at 100 μg·mL⁻¹ and ~80% at intermediate concentrations (50-75 µg·mL Discussion: Curcumin-loaded zein nanocapsules are biocompatible and effective against
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