Evidence map›Paper›PMID 40989140›Full record

ReviewCanadian respiratory journal2025

High-Altitude Pulmonary Embolism: Epidemiology, Pathophysiology, Diagnosis, and Management.

Zhen-Zhong Yang, Jing Li, Zhen-Long Chang, Xiao-Xia Liu, Jun-Peng Ran, Lin-Feng Liu

Abstract readReview
In one paragraph

Review in Canadian respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pulmonary embolism consensus.Archivos de cardiologia de Mexico · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhen-Zhong YangEmergency Department, People's Hospital of Xizang Autonomous Region, Lhasa 850000, China.ORCID 0009-0006-0947-6402
Jing LiCardiovascular Department of Mountain Diseases, People's Hospital of Xizang Autonomous Region, Lhasa 850000, China.ORCID 0009-0008-3269-3362
Zhen-Long ChangEmergency Department, People's Hospital of Xizang Autonomous Region, Lhasa 850000, China.ORCID 0009-0002-3534-8560
Xiao-Xia LiuEmergency Department, People's Hospital of Xizang Autonomous Region, Lhasa 850000, China.ORCID 0009-0006-0414-9533
Jun-Peng RanEmergency Department of People's Hospital of Lhasa, Lhasa 850000, Xizang Autonomous Region, China.ORCID 0009-0003-1381-6797
Lin-Feng LiuDepartment of Anesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.ORCID 0009-0006-3783-1432

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary embolism (PE) at high altitude (HA) is a potentially life-threatening but underrecognized condition. Unlike low-altitude PE, high-altitude pulmonary embolism (HA-PE) may result from unique hypoxia-driven mechanisms, including hemoconcentration, endothelial dysfunction, and a hypercoagulable state. In this narrative review, we summarize current evidence on the epidemiology, pathophysiology, diagnosis, management, and prognosis of HA-PE, based on the literature published between 2010 and 2025 retrieved from PubMed and CNKI. This review summarizes the epidemiological profile, clinical features, altitude-related diagnostic challenges, limitations of current therapeutic strategies, and the prognosis of HA-PE. A more comprehensive understanding of HA-PE is crucial for enhancing early detection and developing altitude-adapted management approaches.

Indexed as

AltitudeAltitude SicknessPulmonary EmbolismHumansPrognosisdiagnosishigh-altitudepathophysiologypulmonary embolismVTE

Identifiers

PMID40989140
PMCPMC12453912

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.