ArticleFrontiers in endocrinology2025
Urinary iodine concentration and thyroid function in pregnant women with hypertensive disorders.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pregnant women are considered a risk group for iodine deficiency, and this condition may be associated with changes in thyroid hormone levels and an increased risk of developing hypertensive disorders. Objective: To assess urinary iodine concentration (UIC), thyroid-stimulating hormone (TSH) and anti-thyroid peroxidase (TPO) antibody levels in pregnant women with hypertensive disorders. Methods: This cross-sectional study was conducted in a referral maternity hospital in Paraíba, Brazil between June 2022 and April 2023. A total of 250 women over 18 years of age, in the third trimester of pregnancy and diagnosed with hypertensive disorders were included. Clinical and epidemiological data, as well as TSH, anti-TPO antibodies and UIC were assessed. Iodine deficiency was defined as UIC levels <150 μg/L. Correlations between UIC and the study variables were analyzed using regression models adjusted with the Results: The median UIC was 82.5 μg/L (95%CI: 72.9-93.8), with 76.4% of participants (n=191) being iodine deficient. UIC differed among hypertensive disorders (p=0.023), with significant differences found between gestational hypertension (111.6 μg/L) and both preeclampsia (61.3 μg/L; p=0.018) and superimposed preeclampsia (70 μg/L; p=0.020). Systolic blood pressure (SBP) and gestational age correlated negatively with UIC (-0.006±0.002, p=0.015; -0.03±0.01, p=0.042, respectively). No correlation was found between UIC and TSH levels or anti-TPO antibodies. Conclusion: Lower UIC levels were observed in pregnant women with pre-eclampsia or superimposed pre-eclampsia compared to women with gestational hypertension, as well as in higher SBP levels and gestational age. Detection of iodine deficiency in pregnancy may help identify women at higher risk of hypertensive complications, and supplementation may potentially improve outcomes.
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