ArticleTransplantation direct2025
Outcomes of Liver Transplantation in Patients With Severe Obesity: The Impact of Performance Status.
Article in Transplantation direct, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Background: This study aims to evaluate the impact of obesity on post-liver transplant outcomes stratified by low- and high-performance status. Methods: Patients undergoing liver transplantation between 2006 and 2023 were identified in the United Network for Organ Sharing data set. Patients with severe obesity body mass index ([BMI] ≥40 kg/m Results: Severe obesity has a significant negative impact on perioperative and long-term outcomes on the low-performance group (LPG). This effect was not observed in the high-performance group. Five-year survival in the high-performance group was 81.7%, compared with 77.9% in the LPG. The multivariable analysis revealed that severe obesity in the LPG increased early graft loss by 53%, and 30- and 90-d mortality by 57% and 50%, respectively ( Conclusions: Severe obesity in patients with a low-performance status before transplantation significantly increases the risk of poor perioperative and long-term outcomes. Interestingly, this effect is not seen in patients with high-performance scores. Additionally, the combination of severe obesity and advanced age in low-performance status patients may have a compounded negative effect on posttransplant survival.
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