Evidence map›Paper›PMID 40989076›Full record

ArticleTransplantation direct2025

Identification of Surrogate Outcome Biomarkers in Lung Allograft Recipients With Bronchiolitis Obliterans: Implications for Randomized Controlled Trials.

Derek E Byers, Ramsey Hachem, Chadi A Hage, Rajat Walia, Hilary Goldberg, Mrunal Patel, John Reynolds, Julia Klesney-Tait, Selim Arcasoy, Chetan Naik and 26 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Utility of donor-derived cell-free DNA testing after lung transplantation in the precision medicine era.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Derek E ByersDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, MI.
Ramsey HachemDivision of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, UT.
Chadi A HageDivision of Pulmonology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.
Rajat WaliaDignity Health, Phoenix, AZ.
Hilary GoldbergDivision of Pulmonology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Mrunal PatelDivision of Pulmonology, Department of Medicine, Indiana University, Indianapolis, IN.
John ReynoldsDivision of Pulmonology, Department of Medicine, Duke University, Durham, NC.
Julia Klesney-TaitDivision of Pulmonology, Department of Medicine, University of Iowa, Iowa City, IA.
Selim ArcasoyDivision of Pulmonology, Department of Medicine, Columbia University, New York, NY.
Chetan NaikDivision of Pulmonology, Department of Medicine, Baylor University Medical Center, Dallas, TX.
Nicoe De SimoneCarter Blood Center, Bedford, TX.
Amena UsmaniDivision of Transfusion Medicine, Department of Pathology, University of California San Diego, San Deigo, CA.
Reda GirgisDivision of Pulmonology, Department of Medicine, Spectrum Health, Grand Rapids, MI.
Francis CordovaDivision of Pulmonology, Department of Medicine, Temple University, Philadelphia, PA.
Brian KellerDivision of Pulmonology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
David NunleyDivision of Pulmonology, Department of Medicine, Ohio State University, Columbus, OH.
Jagadish PatilDivision of Pulmonology, Department of Medicine, University of Minnesota, Minneapolis, MN.
Matthew MorrellDivision of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, UT.
Elizabeth LendermonDivision of Pulmonology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.
Howard J HuangDivision of Pulmonology, Department of Medicine, Houston Methodist Hospital, Houston, TX.
Andres PelaezDivision of Pulmonology, Department of Medicine, University of Florida, Miami, FL.
Amir EmtazooDivision of Pulmonology, Department of Medicine, University of Florida, Gainesville, FL.
Keith WilleDivision of Pulmonology, Department of Medicine, University of Alabama, Birmingham, AL.
Kevin ChanDivision of Pulmonology, Department of Medicine, University of Michigan, Ann Arbor, MI.
Gordon YungDivision of Pulmonology, Department of Medicine, University of California San Diego, San Diego, CA.
Maher BazDivision of Pulmonology, Department of Medicine, Mayo Clinic Jacksonville, Jacksonville, FL.
Shambhu AryalDivision of Pulmonology, Department of Medicine, Inova Medical Center, Falls Church, VA.
Suresh VedanthamClinical Coordinating Center, Washington University School of Medicine, Mallinckrodt Institute of Radiology, St Louis, MI.
Mary Clare DerflerClinical Coordinating Center, Washington University School of Medicine, Mallinckrodt Institute of Radiology, St Louis, MI.
Paul CommeanData Coordinating Center, Washington University School of Medicine, Mallinckrodt Institute of Radiology, St Louis, MI.
Keith BermanHealth Research Associates, Sierra Madre, CA.
Andrew AtkinsonDepartment of Biostatistics, Washington University, St Louis, MI.
Jeff AtkinsonDivision of Pulmonary Medicine, Department of Internal Medicine,Washington University School of Medicine, St Louis, MI.
Alexey ProkudinDivision of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MI.
John McCarthyDepartment of Mathematics, Washington University, St Louis, MI.
George DespotisDivision of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MI.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe developed a prospective, multicenter "registry" to evaluate the effect of extracorporeal photopheresis for lung transplant recipients who develop chronic lung allograft dysfunction (CLAD) with the bronchiolitis obliterans syndrome (BOS) phenotype (CLAD/BOS) and who are refractory to conventional standard-of-care therapy.

methodsData from 258 lung transplant recipients enrolled in the Registry between April 2015 and April 2022 were included in this analysis. All recorded parameters (eg, demographics), including forced expiratory volume in 1 s (FEV

resultsMortality at 6 and 12 mo after CLAD/BOS diagnosis was 5% and 14%, whereas mortality at 6 and 12 mo after enrollment was 15% and 26%, respectively. The primary cause of death in the cohort was respiratory failure or graft failure (74%). Rate of FEV

conclusionsThe rate of FEV

Identifiers

PMID40989076
PMCPMC12453344

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.