ArticleClinical neuropsychiatry2025
Evaluation of Adherence to Pharmacological Treatment in a Large Sample of Patients with Personality Disorder.
Article in Clinical neuropsychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07481890 (Feasibility and Efficacy of an EMDR Psychotherapeutic Intervention With Additional Procedures), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility and Efficacy of an EMDR Psychotherapeutic Intervention With Additional Procedures (EMDR Toolbox Method) in Improving the Psychological Well-Being of Patients Diagnosed With Oncological Disease: A Randomized Study.
Who cites it
3 citing papers in PubMed.
- Article
- A Systematic Review of Personality Disorders in Patients with Gambling Disorder.Clinics and practice · 2026Review
- "It seems like they are guessing": a qualitative study of the prescribing process from the perspective of individuals diagnosed with personality disorder.Frontiers in psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Personality disorders (PDs) are chronic and pervasive mental health conditions associated with significant functional impairment and high psychiatric comorbidity. Although psychotherapeutic interventions are the primary treatment approach, pharmacotherapy is frequently prescribed to manage specific symptoms. However, adherence to pharmacological treatment in PDs remains a critical challenge, influenced by both personality traits and clinical factors. The present study aims to assess adherence rates in a large cohort of patients with PDs and explore potential sociodemographic and clinical factors associated with compliance. Method: This observational study included 200 patients diagnosed with PDs according to DSM-5 criteria, recruited from different psychiatric services in Milan, Italy. Adherence was assessed using the Clinician Rating Scale (CRS), with positive adherence defined as CRS ≥ 5 and poor adherence as CRS < 5. Sociodemographic and clinical data were collected and analyzed across adherence groups and PD clusters. Results: Positive adherence was observed in 64.5% of the sample. Cluster C PDs exhibited significantly higher adherence rates (83.3%) compared to Cluster B (61.3%), mixed-feature (60%), and Cluster A (73.3%; p<.05). A positive family history of psychiatric disorders was associated with greater adherence (60.3% vs. 45.5%, p<.05). A trend toward lower adherence was observed in patients with lifetime and current substance use. Conclusions: Higher adherence in Cluster C PDs may be linked to anxiety-driven behavioral patterns, while lower adherence in Cluster B and mixed-feature PDs suggests impulsivity and mistrust contribute to non-compliance. Additionally, a positive family history of psychiatric disorders emerged as a potential protective factor, possibly enhancing treatment engagement through greater awareness and support networks. Future research should focus on developing tailored interventions to the specific needs of different PD clusters to improve long-term treatment outcomes.
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