ArticleiScience2025
T cell monocyte complexes exhibit distinct immune signatures during infection.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- A high-resolution blood immune cell doublet atlas via imaging spectral cytometry.bioRxiv : the preprint server for biology · 2026Article
- Decoding Immune Cell Doublets in Humans: From Artifacts to Insights.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2026Review
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Authors and funding
18 authors.
Funding
Abstract
Communication between immune cells through direct contact is a critical feature of immune responses. Here, we developed an innovative high-throughput workflow to study the transcriptome and adaptive immune receptor repertoire of single cells forming complexes without needing bioinformatic deconvolution. We found that T cells and monocytes forming complexes in blood during active tuberculosis (TB) and dengue hold distinct transcriptomic signatures from singlets, with the upregulation of genes associated with immune activation and MHC-II complex. Additionally, in TB, T cells in complexes showed enrichment for cytotoxic T cells, higher TCR clonality, and increased immune activity at diagnosis compared to after anti-TB therapy. We also found that T cells and monocytes forming complexes were markedly enriched for "dual-expressing" cells (i.e., co-expressing T cell and monocyte genes), suggesting intercellular RNA acquisition occurs during cell-cell interactions. Thus, studying immune cell complexes at single-cell resolution provides insights into immune cell-cell interactions in the blood during infection.
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Registered trials
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