ArticleiScience2025
Local activation of Cxcl12a signaling controls olfactory placode morphogenesis in zebrafish embryos.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Protocol to explore olfactory placode morphogenesis using an agent-based model.STAR protocols · 2026Article
- Mechanical constraints on cell plasticity: insights from the olfactory epithelium.Frontiers in cell and developmental biology · 2026Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphogenesis and cell-type differentiation are highly coordinated in sensory organs to ensure their function. Morphogenesis of the olfactory placode in zebrafish provides a unique model to study this process as undifferentiated cells aligned around the anterior neural plate mature into clusters of early olfactory neurons across a short timescale. Although the Cxcl12a/Cxcr4b signaling pathway drives this process, what constraints on pathway activation apply during morphogenesis are unclear. We developed a mathematical model recapitulating Cxcl12a-mediated olfactory placode morphogenesis. Restoring Cxcl12a expression in mutants for the ligand rescues correct morphogenesis both
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Registered trials
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