ArticleCureus2025
Chlorpheniramine Maleate Displaying Multiple Modes of Antiviral Action Against SARS-CoV-2: An Initial Mechanistic Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Chlorpheniramine maleate (CPM) has been identified as a potential antiviral compound against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Materials and methods The antiviral activity of CPM against SARS-CoV-2 was evaluated in vitro using Vero E6 cells. Cytotoxicity and antiviral assays assessed effects on viral adsorption, replication, and virucidal activity. Molecular docking was conducted to explore interactions with viral proteins and the angiotensin-converting enzyme 2 receptor. Results Our findings demonstrate that CPM exhibits antiviral properties by interfering with viral adsorption and replication, as well as directly inactivating the virus. Molecular docking analysis revealed interactions between CPM and essential viral proteins, such as the main protease receptor, spike protein receptor, and RNA polymerase. CPM's interactions were primarily hydrophobic in nature, with an additional hydrogen bond formation in the RNA polymerase active site. Conclusions These results suggest that CPM has the potential to serve as a multitarget antiviral agent against SARS-CoV-2 and potentially other respiratory viruses. Further investigations are warranted to explore its clinical implications and assess its efficacy in vivo.
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