ArticleClinical, cosmetic and investigational dermatology2025
Preliminary Histological Evidence of Epidermal and DEJ Remodeling with Microneedling-Assisted Topical Exosome Therapy: A Single-Subject Case Report.
Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A Split-Scar Study: Study of Surgical Scar Using Exosomes.Journal of cosmetic dermatology · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to evaluate the histological effects of microneedling-assisted topical exosome therapy on the dermoepidermal junction (DEJ) and surrounding epidermal structures in aging skin. Patients and Methods: In this single-subject case report, a healthy 63-year-old male with no known dermatologic or systemic conditions underwent a single session of 0.3 mm microneedling immediately followed by topical application of an exosome-based formulation (E-50 Skin Booster, PrimaCure Co., Ltd., Korea). A 3 mm punch biopsy was collected from the postauricular area at baseline, and a follow-up biopsy was obtained eight weeks post-treatment from an adjacent site. Hematoxylin and eosin (H&E) staining was performed, and histomorphometric parameters were analyzed using high-resolution imaging and AI-assisted quantitative tools. Results: Histological analysis revealed significant remodeling of the DEJ, with a 17.08% increase in rete ridge count ( Conclusion: Microneedling-assisted topical exosome therapy produced notable structural improvements at the epidermal and dermoepidermal levels in aging skin. Restoration of rete ridges, enhanced keratinocyte proliferation, and increased collagen density suggest a promising role for this combined approach in skin rejuvenation. These findings are specific to microneedling-assisted topical delivery and should not be interpreted as supporting the use of injectable exosomes, which were not evaluated in this study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.