Evidence map›Paper›PMID 40988913›Full record

ReviewSleep and biological rhythms2025

Efficacy and safety of intraoperative esketamine for postoperative sleep quality: a systematic review and meta-analysis of RCTs.

Min Zeng, Mingliang Yi, Hong Yin, Tingting Zheng, Ying Peng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Sleep and biological rhythms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Min ZengGeriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Department of Anesthesiology, Chengdu Fifth People's Hospital, The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), 33 Ma Shi Street, Wenjiang District, Chengdu, 611137 Sichuan Province China.ORCID 0000-0002-4137-1743
Mingliang YiGeriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Department of Anesthesiology, Chengdu Fifth People's Hospital, The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), 33 Ma Shi Street, Wenjiang District, Chengdu, 611137 Sichuan Province China.
Hong YinGeriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Department of Anesthesiology, Chengdu Fifth People's Hospital, The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), 33 Ma Shi Street, Wenjiang District, Chengdu, 611137 Sichuan Province China.
Tingting ZhengGeriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Department of Anesthesiology, Chengdu Fifth People's Hospital, The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), 33 Ma Shi Street, Wenjiang District, Chengdu, 611137 Sichuan Province China.
Ying PengGeriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Department of Anesthesiology, Chengdu Fifth People's Hospital, The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), 33 Ma Shi Street, Wenjiang District, Chengdu, 611137 Sichuan Province China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the efficacy and safety of intraoperative esketamine in improving postoperative sleep quality based on evidence from randomized controlled trials (RCTs). A systematic search was conducted in the Cochrane Central Register of Controlled Trials (CENTRAL), Medline (via Ovid), and EMBASE. Eligible studies were RCTs comparing the effects of esketamine versus placebo on postoperative sleep quality in surgical patients. Statistical analyses were performed using Cochrane Review Manager version 5.4.1. A total of 10 RCTs comprising 1,287 patients were included. Esketamine significantly improved postoperative sleep quality compared to placebo on postoperative day (POD) 1 (SMD =  - 0.52, 95% CI [- 0.69, - 0.34], Supplementary Information: The online version contains supplementary material available at 10.1007/s41105-025-00595-8.

Indexed as

EsketamineMeta-analysisPostoperative sleep quality

Identifiers

PMID40988913
PMCPMC12450849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.