ArticleJournal of oral microbiology2025
Identification and functional validation of kynureninases from oral bacteria.
Article in Journal of oral microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The kynurenine (KYN) pathway produces key metabolites for immunoregulation and neuromodulation in humans, but its presence and activity in the oral microbiome are unclear. This study investigates the functionality of the key kynureninase (KynU), which catalyses kynurenine to anthranilic acid (AA), in oral bacteria. Methods: Bioinformatic analysis identified putative Results: Among 71 species, seven oral bacteria were identified to possess the Conclusions: This study demonstrates KynU activity in oral bacteria, revealing an unrecognised aspect of microbial metabolism with potential implications for host-microbe interactions. Further investigation is required to elucidate the biological significance of bacterial KYN metabolites and their role in oral diseases.
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