Evidence map›Paper›PMID 40988888›Full record

ArticleAccess microbiology2025

Functional characterization of engineered bacterial biosensors for kynurenine detection.

Pisit Charoenwongwatthana, Halah Ahmed, Wojciech Cajdler, Jamie Coulter, Chien-Yi Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Access microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pisit CharoenwongwatthanaSchool of Dental Sciences, Faculty of Medical Sciences Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK.ORCID https://orcid.org/0000-0002-6633-4877
Halah AhmedSchool of Dental Sciences, Faculty of Medical Sciences Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK.ORCID https://orcid.org/0000-0002-2121-0811
Wojciech CajdlerSchool of Dental Sciences, Faculty of Medical Sciences Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK.ORCID https://orcid.org/0009-0009-8015-1346
Jamie CoulterSchool of Dental Sciences, Faculty of Medical Sciences Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK.ORCID https://orcid.org/0000-0002-6328-7702
Chien-Yi ChangSchool of Dental Sciences, Faculty of Medical Sciences Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK.ORCID https://orcid.org/0000-0003-3570-4019

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The kynurenine (KYN) pathway is the major catabolic pathway for tryptophan in humans, producing several metabolites that influence health. In clinical settings, KYN levels serve as a valuable biomarker for the diagnosis and prognosis of inflammatory and neurological diseases. Nevertheless, KYN detection relies on mass spectrometry analysis, which requires specialized knowledge and expertise with high operational costs. The bacterial biosensor presents as a promising tool for rapid and cost-effective targeted substance detection due to its ease of genetic modification. Therefore, this study aimed to develop an engineered bacterial biosensor by integrating a genetic module in a plasmid designed for KYN detection harboured in an

Indexed as

bioengineeringbiosensorkynureninesynthetic biologytryptophan

Identifiers

PMID40988888
PMCPMC12451312

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.