ReviewFrontiers in microbiology2025
Climatic and endothermic thermal stress adaptation may be a major driver of emerging and emergent multidrug resistant fungi.
Review in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- A review on fungal pathogens in the One Health framework: connecting plant, animal, and human health.Archives of microbiology · 2026Review
- Thermal adaptation crosstalk with azole response through lncRNA inbioRxiv : the preprint server for biology · 2026Article
- Thermotolerant insect-associated selective pressure may drive increased lipid metabolic plasticity and emerging pathogenic potential in yeasts.Frontiers in microbiology · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The impact of climate change and increasing global temperature is contributing to the emergence of unknown and the reemergence of known fungal pathogens. Main body: In the process of adapting to the increasing global temperatures, some fungi have evolved multidrug resistance traits thus narrowing the therapeutic options in our antifungal arsenal. Interestingly, all emerging fungal pathogens and known emergent fungi are multidrug and pandrug resistant, suggesting that the drug resistance traits observed are partly due to thermal stress-induced cross stress-responses. This paper argues that the acquired drug resistance traits may also be driving increased virulence and adaptation to infection-related conditions, resulting in the outbreak of community and hospital infections. Conclusion: Continued surveillance and more research are required to enhance our understanding of the impact of heat-induced evolution of antifungal resistance in this rapidly evolving area of research that may define a new era in medical mycology.
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Registered trials
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