ArticleCureus2025
Functional and Blood-Based Biomarkers of Brain Aging in Senior Airline Pilots Approaching Mandatory Retirement: A Case-Control Comparison With Age-Matched Office Workers.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- A psychological network analysis of self-reported spatial cognitive strategies in commercial airline pilots and non-pilots.Frontiers in human neuroscience · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background While mandatory retirement ages for commercial air transport (CAT) pilots are based on assumptions about age-related cognitive decline, empirical evidence examining brain aging in senior professionals in this field remains scarce. The aim of this study was to compare functional and blood-based biomarkers of brain aging between senior CAT pilots approaching retirement and age-matched office workers. Methods We conducted a case-control study involving 31 male CAT pilots aged 60-64 years and 31 age- and sex-matched office workers. Following the Aging Biomarker Consortium framework, we assessed functional biomarkers of brain aging, including processing speed (Trail Making Test Part A), episodic memory (Cued Recall Test and Auditory Verbal Learning Test [AVLT]), and fine motor control (Nine-Hole Pegboard Test). In addition, plasma concentrations of phosphorylated tau-181 (p-tau181) and neurofilament light chain (NfL) were measured as blood-based biomarkers of brain aging. Results Senior CAT pilots demonstrated significantly superior processing speed (Trail Making Test Part A: 26.8 ± 4.1
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