ArticleInternational journal of general medicine2025
The Influence of Characteristics and Indexes (NLR, PNI, and SII) Evaluated at Admission on the Mortality Prediction of Infectious Endocarditis Patients.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Changing Epidemiology, Healthcare-Associated Infections, and Outcomes in Infective Endocarditis: A Five-Year Retrospective Study from a Tertiary Cardiovascular Center.Medicina (Kaunas, Lithuania) · 2026Article
- Management and outcomes of infective endocarditis in a community hospital and its cardiac surgery referral centre.Scientific reports · 2026Article
- Prognostic Value of HALP Score for In-Hospital Mortality in Patients with Infective Endocarditis.Journal of clinical medicine · 2026Article
- A risk prediction model based on immune-inflammatory-nutritional indicators for predicting 28-day mortality in sepsis patients with acute respiratory distress syndrome.Frontiers in nutrition · 2026Article
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Authors and funding
9 authors.
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Abstract
Background: Infective endocarditis (IE) is a serious and potentially life-threatening infection with high morbidity and mortality. Early risk identification is critical for enabling timely treatment and preventing adverse outcomes. Recently, several low-cost and accessible inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), prognostic nutritional index (PNI), and systemic immune-inflammation index (SII), have gained attention for their potential prognostic value in infectious diseases. Methods: This retrospective study evaluated patients diagnosed with definite IE between May 2014 and May 2024 at Bakırköy Dr. Sadi Konuk Training and Research Hospital. Clinical characteristics, laboratory parameters, complications, and outcomes were compared between survivors and non-survivors. The predictive value of NLR, PNI, and SII for in-hospital mortality was assessed. Results: A total of 78 patients with IE were included, with an overall mortality rate of 52.5%. Non-survivors were significantly older (p = 0.001) and had higher rates of cardiac complications (p < 0.05). PNI values were significantly lower in non-survivors (p = 0.014). Undergoing cardiac surgery was associated with a lower mortality rate (p = 0.024). Conclusion: PNI, a simple, inexpensive, and readily available marker, may provide valuable prognostic information in patients with infective endocarditis. This index could help in early risk stratification and clinical decision.
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