Evidence map›Paper›PMID 40988751›Full record

ArticleFrontiers in medicine2025

The relationship between the intraocular position of dexamethasone intravitreal implant and post-injection intraocular pressure elevation.

Dingxi Liu, Yue Chen, Xiaonan Fu, Yongxia Zhao, Lili Ji, Yuanyuan Qiu, Sheng Li

Abstract read
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dingxi LiuDepartment of Ophthalmology, The Third People's Hospital of Dalian, Dalian, China.
Yue ChenDepartment of Ophthalmology, The Third People's Hospital of Dalian, Dalian, China.
Xiaonan FuDepartment of Ophthalmology, The Third People's Hospital of Dalian, Dalian, China.
Yongxia ZhaoDepartment of Ophthalmology, The Third People's Hospital of Dalian, Dalian, China.
Lili JiDepartment of Ophthalmology, The Third People's Hospital of Dalian, Dalian, China.
Yuanyuan QiuDepartment of Ophthalmology, The Third People's Hospital of Dalian, Dalian, China.
Sheng LiDepartment of Ophthalmology, The Third People's Hospital of Dalian, Dalian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the relationship between the implantation position of dexamethasone intravitreal implant (DEX-I) and post-injection intraocular pressure (IOP) elevation. Methods: This retrospective study included 324 patients (332 eyes) who received at least one DEX-I injection between June 2020 and June 2024, with a follow-up period of at least 3 months. Patient demographics, diagnoses, and DEX-I implantation positions were recorded. The correlation between implantation position and post-injection IOP elevation was analyzed. IOP elevation was defined as an IOP greater than 25 mmHg and/or an increase of 10 mmHg from baseline. DEX-I implantation positions were defined as follows: P1: implant located in the vitreous near the ciliary body, anterior to the ora serrata (with or without ciliary body contact); P2: implant located in the vitreous from the ora serrata to the pre-equatorial region; P3: implant located in the post-equatorial vitreous. The equator was defined by the vortex veins. Results: During the follow-up period, 68 eyes (20.48%) experienced IOP elevation. Compared to P2 and P3, the P1 implantation position was significantly associated with a higher incidence of IOP elevation ( Conclusion: The P1 implantation is positively correlated with IOP elevation, particularly with early IOP elevation.

Indexed as

dexamethasone intravitreal implantDEX-iimplantation positionintraocular pressure elevationIOP

Identifiers

PMID40988751
PMCPMC12450912

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