ArticleFrontiers in medicine2025
Miller-Fisher syndrome presenting with headache and ophthalmoparesis: a case report and literature review.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Miller-Fisher Syndrome Presenting With Severe Headache and Transient Loss of Consciousness: A Case Report From Yemen.Clinical medicine insights. Case reports · 2026Article
- Anti-GQ1b antibody syndrome presenting as acute ophthalmoplegia with pupillary involvement and blepharoptosis: a case report and literature review.International journal of ophthalmology · 2026Article
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4 authors.
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Abstract
Miller-Fisher syndrome (MFS) is a rare variant of Guillain-Barre syndrome, classically characterized by a triad of symptoms, including ataxia, areflexia, and ophthalmoplegia. However, only a few cases have documented clinical data on a rare atypical presentation of MFS, with headache and ophthalmoplegia as the initial manifestation. We report an 83-year-old Chinese female patient with no history of respiratory or gastrointestinal infection presented with headache and ophthalmoplegia. Cerebrospinal fluid analysis showed albuminocytological dissociation, along with positive anti-GQ1b antibodies, leading to a diagnosis of incomplete Miller-Fisher syndrome. The patient's headache symptoms were relieved following immunoglobulin treatment, and ophthalmoplegia resolved within 20 days. A literature search identified eight cases of MFS patients initially presenting with headaches, followed by ophthalmoplegia. Detection of anti-ganglioside antibodies in serum or cerebrospinal fluid enables early diagnosis of MFS, and early immunoglobulin treatment improves patient prognosis.
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