ArticleJournal of nutritional science2025
Catechin (epigallocatechin-3-gallate) supplement restores the oxidation: antioxidation balance through enhancing the total antioxidant capacity in Wistar rats with cadmium-induced oxidative stress.
Article in Journal of nutritional science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Bioactivity assessment and LC-MS/MS-based phenolic characterization of Gypsophila pilosa.Scientific reports · 2026Article
- Oral whole-leaf matcha partially attenuates UV-induced dermoepidermal disruption and collagen phenotype alterations in a rat model of repeated photoaging.Frontiers in medicine · 2026Article
- Non-steroidal anti-inflammatory drugs conjugated to a synthetic peptide exhibitRSC medicinal chemistry · 2025Article
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Authors and funding
11 authors.
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Abstract
Catechins are bioactive flavanols commonly found in the fruits and leaves of plants, particularly the fresh tea leaves. This experimental study aims to evaluate the antioxidant properties of epigallocatechin-3-gallate, one of the most prominent catechins, and its ability to mitigate cadmium-induced oxidative stress. Eighty rats were randomly assigned to four groups of 20: an untreated control group (group 1), a catechin-treated group (group 2), a cadmium-exposed group (group 3), and a cadmium-catechin group (group 4). Group 2 rats received daily oral doses of catechin at 300 mg/kg body weight, while Group 3 rats were given an aqueous solution of cadmium chloride at a final concentration of 5 mg/kg body weight (b.w.) per day. Group 4 rats were treated with both catechin and cadmium chloride. The rats in Group 4 exhibited increased levels of total proteins and significant increases in antioxidant markers, including total thiols, glutathione, total antioxidant capacity, superoxide dismutase, glutathione peroxidase, and catalase. Additionally, this group demonstrated significant decreases in blood cadmium levels and in the following enzymes: alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase. They also demonstrated significant decreases in creatinine, blood urea nitrogen, urea, and bilirubin, as well as in oxidation markers (H
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