ArticleJournal of mood and anxiety disorders2025
An examination of anhedonia as a predictor of response with transcranial magnetic stimulation treatment for youth with depression.
Article in Journal of mood and anxiety disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This exploratory study examined the relationship between the change in anhedonia symptoms and treatment response in adolescents receiving 1 Hz or 10 Hz transcranial magnetic stimulation (TMS) treatment for major depressive disorder (MDD). Participants were aged 12-18 years, had a depressive symptom score of 40 or higher on the Children's Depressed Rating Scale-Revised (CDRS-R), and were randomized to either the 1 Hz (n = 22) or 10 Hz (n = 19) group for 30 daily TMS treatments over the left dorsolateral prefrontal cortex (LDLPFC). Anhedonia was measured using items from the Beck Depression Inventory-II and CDRS-R. Treatment outcome was assessed with the Clinical Global Impressions-Improvement scales (CGI-I). Logistic regression was used to estimate the odds of CGI-I treatment response from the change in anhedonia symptoms (baseline to week 6), and a linear mixed model of repeated measures analyzed the change in anhedonia (baseline, weeks 4 and 6) compared between the TMS treatment groups over the 6-week study period. TMS stimulus frequency did not affect the change in anhedonia and CGI-I response. There was a significant inverse relationship concerning the change in anhedonia symptoms and CGI-I response for both the 10 Hz (p = 0.0109, δ= -0.8581, SE= 0.3371) and 1 Hz (p = 0.0277, δ= -1.1017, SE=0.5003) groups. Thus, as anhedonia symptoms improved over the 6 weeks, the probability of CGI-I response at week 6 increased for both the 1 Hz and 10 Hz TMS groups. An adjusted least squares for anhedonia revealed a significant improvement in anhedonia for TMS groups (10 Hz, p < 0.0001,
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