ArticleJournal of veterinary internal medicine
Evaluation of Immune System Components in Dogs With Protein-Losing Enteropathy Compared to Healthy Controls.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Letter regarding "ACVIM-endorsed statement: consensus statement and systematic review on guidelines for the diagnosis and treatment of chronic inflammatory enteropathy in dogs".Journal of veterinary internal medicine · 2026Article
- Evaluation of Immune System Components in Dogs With Protein-Losing Enteropathy Compared to Healthy Controls.Journal of veterinary internal medicineArticle
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
backgroundImmune system abnormalities including hypogammaglobulinemia and T-cell deficiency occur in humans with protein-losing enteropathy (PLE). It is unknown whether similar abnormalities occur in dogs with PLE.
objectiveTo evaluate serum immunoglobulin (Ig) concentrations and immune cell populations in dogs with PLE (with histologic evidence of chronic inflammatory enteropathy, intestinal lymphangiectasia (IL), or both) compared to healthy controls (HC). ANIMALS: Eighteen dogs with PLE and 18 HC dogs.
methodsProspective study. Serum IgA, IgG, and IgM concentrations were measured via ELISA in treatment-naïve dogs with PLE and compared to concentrations in HC dogs. RNA gene expression of specific immune cell surface markers in peripheral blood mononuclear cells (PBMCs) was measured in both groups by quantitative PCR.
resultsDogs with PLE had lower concentrations of serum IgG compared to HC dogs (4.5 mg/mL, range 0.67-22.4 mg/mL vs. 19 mg/mL, range 1.8-80.3 mg/mL; p < 0.001). Serum IgM concentrations were also lower in dogs with PLE versus HC (2.4 mg/mL, range 0.0009-53.1 mg/mL vs. 14.2 mg/mL, range 2.1-172.8 mg/mL; p = 0.002). Expression of CD3e (0.24, range 0.003-1.1 vs. 0.92, range 0.41-3.2; p < 0.001), CD5 (0.17, range 0.01-0.46 vs. 0.94, range 0.23-5; p < 0.001), and CD8 (0.47, range 0.06-1.7 vs. 0.92, range 0.32-2.4; p = 0.007) were reduced in dogs with PLE compared to their mean absolute expression in HC dogs. CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with PLE have quantitative reductions in immune system components, similar to humans with IL. These abnormalities in immune system components might be considered in the management and monitoring of dogs with PLE.
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