Evidence map›Paper›PMID 40988612›Full record

Observational studyCirculation. Cardiovascular imaging2025

Myocardial Entropy and Risk Predictors in Hypertrophic Cardiomyopathy: An Analysis From the NHLBI HCM Registry.

Panagiotis Antiochos, Yin Ge, Michael Jerosch-Herold, Louis-Philippe David, Bobak Heydari, Paul Kolm, Dong-Yun Kim, Rob J van der Geest, Hugh Watkins, Milind Y Desai and 11 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Circulation. Cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01915615 (HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01915615 active not recruitingnot on this map

HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy

Typeobservational_patient_registrySponsorUniversity of VirginiaRan2014 to 2025Enrolled2,750ConditionsHypertrophic CardiomyopathyArmsNone - this is an observational study
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Panagiotis Antiochos *Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA (P.A., Y.G., M.J.-H., L.-P.D., C.Y.H., R.Y.K.).ORCID 0000-0001-8466-7360
Yin Ge *Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA (P.A., Y.G., M.J.-H., L.-P.D., C.Y.H., R.Y.K.).
Michael Jerosch-HeroldCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA (P.A., Y.G., M.J.-H., L.-P.D., C.Y.H., R.Y.K.).ORCID 0000-0001-9018-6731
Louis-Philippe DavidCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA (P.A., Y.G., M.J.-H., L.-P.D., C.Y.H., R.Y.K.).ORCID 0000-0002-0779-2974
Bobak HeydariDepartment of Cardiac Sciences, Stephenson Cardiac Imaging Center, University of Calgary, Canada (B.H.).
Paul KolmDivision of Cardiology, MedStar Heart and Vascular Institute, Washington, DC (P.K., S.F.D., W.S.W.).ORCID 0000-0003-2653-5452
Dong-Yun KimDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (D.-Y.K., P.D.-N.).ORCID 0000-0001-9405-4840
Rob J van der GeestDepartment of Radiology, Leiden University Medical Center, the Netherlands (R.J.v.d.G.).ORCID 0000-0002-9084-5597
Hugh WatkinsRadcliffe Department of Medicine, University of Oxford, United Kingdom (H.W., S.K.P., S.N.).ORCID 0000-0002-5287-9016
Milind Y DesaiDepartment of Cardiovascular Medicine, Cleveland Clinic, OH (M.Y.D.).ORCID 0000-0003-0010-9797
Carolyn Y HoCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA (P.A., Y.G., M.J.-H., L.-P.D., C.Y.H., R.Y.K.).ORCID 0000-0002-7334-7924
Sarahfaye F DolmanDivision of Cardiology, MedStar Heart and Vascular Institute, Washington, DC (P.K., S.F.D., W.S.W.).ORCID 0000-0003-3651-9069
Patrice Desvigne-NickensDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (D.-Y.K., P.D.-N.).ORCID 0000-0003-1073-641X
Martin S MaronHypertrophic Cardiomyopathy Center, Lahey Hospital and Medical Center, Boston, MA (M.S.M.).ORCID 0000-0002-9923-3853
Jeanette Schulz-MengerDepartment of Cardiology and Nephrology, Charité Experimental Clinical Research Center and Helios Clinics Berlin-Buch, Germany (J.S.-M.).ORCID 0000-0003-3100-1092
Stefan K PiechnikRadcliffe Department of Medicine, University of Oxford, United Kingdom (H.W., S.K.P., S.N.).ORCID 0000-0002-0268-5221
Evan AppelbaumMen's Health, Boston, MA (E.A.).
William S WeintraubDivision of Cardiology, MedStar Heart and Vascular Institute, Washington, DC (P.K., S.F.D., W.S.W.).ORCID 0000-0002-5384-5571
Stefan NeubauerRadcliffe Department of Medicine, University of Oxford, United Kingdom (H.W., S.K.P., S.N.).ORCID 0000-0001-9017-5645
Christopher M KramerCardiovascular Division, University of Virginia Health, Charlottesville (C.M.K.).ORCID 0000-0003-2057-7731
Raymond Y KwongCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA (P.A., Y.G., M.J.-H., L.-P.D., C.Y.H., R.Y.K.).ORCID 0000-0001-8212-0759

Funding

HCMR Novel Markers of Prognosis in Hypertrophic CardiomyopathyU01HL117006 · NHLBI · UNIVERSITY OF VIRGINIA · PI KRAMER, CHRISTOPHER M., NEUBAUER, STEFAN · 2013 to 2017
$14.5M
NHLBI NIH HHS U01 HL117006
6 · The paper itself

Abstract

backgroundEntropy, a novel measure of myocardial tissue heterogeneity by cardiovascular magnetic resonance imaging, may have clinical value in patients with hypertrophic cardiomyopathy (HCM). We aimed to investigate the associations of entropy with risk predictors in HCM, using the National Heart, Lung, and Blood Institute HCM Registry.

methodsEntropy values were calculated using the probability distribution of pixel signal intensities of the left ventricular (LV) myocardium on the late gadolinium enhancement (LGE) short-axis stack images. Entropy values were correlated with demographic, genetic, imaging, and serum biomarkers as well as ambulatory Holter recordings and the European Society of Cardiology risk score of sudden cardiac death at 5 years.

resultsAmong 1736 patients with HCM, LV entropy demonstrated significant associations with sarcomere mutations, history of ventricular tachycardia, atrial fibrillation, and elevation of cTnT (cardiac troponin T) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels (

conclusionsIn patients with HCM, LV entropy demonstrated associations with clinical, imaging, and biological predictors of adverse outcomes independent of LGE presence and was the strongest predictor of ventricular tachycardia on Holter. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01915615.

Indexed as

Cardiomyopathy, HypertrophicMagnetic Resonance Imaging, CineMyocardiumVentricular Function, LeftAdultAgedBiomarkersDeath, Sudden, CardiacElectrocardiography, AmbulatoryEntropyFemaleHeartHumansMaleMiddle AgedNational Heart, Lung, and Blood Institute (U.S.)Biomarkerscardiomyopathy, hypertrophicdeath, sudden, cardiacentropygadoliniumtachycardia, ventricular

Identifiers

PMID40988612
PMCPMC12757756

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.