ArticleEnvironmental analysis, health and toxicology2025
Simultaneous analysis of cotinine and 8-OHdG in urine: A biomarker approach for smoking exposure and oxidative stress.
Article in Environmental analysis, health and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
This study developed and validated a simultaneous LC-MS/MS method to quantify cotinine and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in urine, biomarkers for smoking exposure and oxidative DNA damage. The method demonstrated high specificity, sensitivity, and reproducibility, with detection limits of 0.23 ng/mL for cotinine and 0.5 ng/mL for 8-OHdG. Cross-laboratory validation showed strong agreement between institutions, with Pearson correlation coefficients and intraclass correlation coefficients exceeding 0.9. Analysis of urine samples from children and adults revealed that cotinine and 8-OHdG levels were significantly higher in smokers, and also influenced by age, gender, and alcohol consumption. The findings underscore the potential of these biomarkers for assessing smoking-related oxidative stress and health risks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.