ArticleBrain and behavior2025
Association Between Cumulative Atherogenic Index of Plasma and New-Onset Stroke Among Middle-Aged and Elderly Chinese Patients With Stages 0-3 Cardiovascular-Kidney-Metabolic Syndrome: A Longitudinal Cohort Study.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Effectiveness of plasma atherogenic index as a predictor of cardiovascular risk in patients with metabolic syndrome and related cardiometabolic conditions: a systematic review.Cardiovascular endocrinology & metabolism · 2026Review
- Cardiovascular-kidney-metabolic syndrome: a comprehensive review of pathophysiology, epidemiology, diagnosis, and management.Cardiovascular diabetology · 2026Review
- Association Between Cumulative Atherogenic Index of Plasma and New-Onset Stroke Among Middle-Aged and Elderly Chinese Patients With Stages 0-3 Cardiovascular-Kidney-Metabolic Syndrome: A Longitudinal Cohort Study.Brain and behavior · 2025Article
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6 authors.
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Abstract
backgroundCardiovascular-kidney-metabolic (CKM) syndrome represents the interaction among chronic kidney disease, cardiovascular disease, and metabolic disorders. However, the association between the cumulative atherogenic index of plasma (CumAIP) and the risk of incident stroke in individuals with CKM syndrome has not been fully established.
methodsData were obtained from the China Health and Retirement Longitudinal Study (CHARLS). A total of 4674 participants were categorized into quartiles according to CumAIP values and further stratified by CKM syndrome stages (0-3). Multivariable Cox regression models were applied to examine the relationship between CumAIP and incident stroke, while restricted cubic spline (RCS) models were used to explore potential nonlinear associations. Subgroup analyses evaluated possible effect modifications by age, sex, smoking, alcohol consumption, hypertension, and diabetes.
resultsOver the follow-up period, 261 (5.6%) incident strokes were documented, with incidence increasing from 2.5% in CKM stages 0 and 1 to 6.3% in stages 2 and 3. After adjusting for potential confounders, each unit increase in CumAIP was associated with a 149% higher risk of incident stroke (hazard ratio [HR] = 2.49, 95% confidence interval [CI]: 1.69-3.65). Participants in the highest CumAIP quartile showed a 144% higher risk compared with those in the lowest quartile (HR = 2.44, 95% CI: 1.61-3.70). RCS analysis suggested a linear association (p for nonlinearity = 0.182).
conclusionHigher CumAIP is significantly associated with increased risk of incident stroke, particularly among individuals with advanced CKM stages and high-risk subgroups, including older adults, smokers, and those with diabetes.
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