ArticleInfectious diseases of poverty2025
Ecological dynamics of field Aedes albopictus populations under Wolbachia-mediated suppression.
Article in Infectious diseases of poverty, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Advances in mosquito gut microbiota: Mechanisms of regulating pathogen transmission and applications in vector control.Virulence · 2026Review
- An Ecological Impact Assessment Framework and Integrated Management Pathway for Large-Scale Chemical Mosquito Control in Urban Areas.ACS environmental Au · 2026Article
- ModellingJournal of pest science · 2026Article
- Insecticide resistance levels, spatial distribution, and kdr mutations in the dengue vector Aedes albopictus of Hong Kong.PLoS neglected tropical diseases · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundThe incompatible insect technique (IIT), based on Wolbachia-induced conditional sterility, has proven highly effective in suppressing mosquito populations for dengue control. However, concerns that accidental release of infected females could drive population replacement have prompted integration of IIT with irradiation or advanced sex-separation technologies. Moreover, the broader ecological consequences of IIT-based suppression remain insufficiently understood. Here, we investigated whether standalone IIT, leveraging Wolbachia-associated fitness costs under real-world conditions, can effectively suppress Aedes albopictus populations without causing replacement, while also addressing key ecological concerns related to IIT-based mosquito population suppression.
methodsWe conducted field trials on Shazai Island, Nansha District, Guangzhou, China, releasing approximately 16,000 Wolbachia wPip-transinfected A. albopictus HC males per hectare per week from 2018 to 2019, following three years of combined IIT and sterile insect technique (SIT) application. Population suppression was monitored, with wPip infection frequency assessed to evaluate population replacement risks. Two-dimensional system of ordinary differential equations incorporating Wolbachia-induced fitness costs was established to predict population dynamics. Additionally, we assessed female mating preferences after three years of suppression and the impact on non-target Culex quinquefasciatus populations.
resultsWe offer both empirical evidence and a mathematical model, demonstrating that the fitness costs associated with a Wolbachia triple-strain infection in A. albopictus, especially in adverse field conditions, empower a standalone IIT to effectively suppress mosquito populations without causing population replacement. Remarkably, reducing the previous release numbers to just 20% sustained a similar suppression level. We found no evidence of changes in female mating preferences after a three-year field suppression. The suppression of A. albopictus does not impact the population of the coexisting nontarget species C. quinquefasciatus. After stopping releases, the population rebounded partially in Year 1 and appeared to fully recover in Year 2, with the rate of this recovery likely influenced by mosquito immigration associated with population flow.
conclusionsOur study demonstrates the robustness, cost-effectiveness, scalability, and ecological safety of IIT as a tool for controlling mosquito-borne diseases. These findings support the implementation of field-applicable, low-dose IIT for sustainable dengue control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.