ReviewLaboratory animal research2025
Rodent research of attention-deficit/hyperactivity disorder: insights into widely used animal models.
Review in Laboratory animal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Sex- and age-dependent mitochondrial dysfunction and cognitive impairment in a mouse model of familial hypercholesterolemia.Biology of sex differences · 2026Article
- The developmental dopamine trajectory hypothesis of ADHD across the lifespan.Frontiers in psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Numerous rodent research models of attention-deficit/hyperactivity disorder (ADHD) have been proposed, including pharmacological, environmental, and genetically generated models. A rodent model for studying ADHD should demonstrate similarities to the disorder by mimicking its three core symptoms (face validity), should align with a theoretically justified pathophysiological basis (construct validity), and should provide insights into unknown aspects of ADHD neurobiology while offering potential new treatments (predictive validity). This review provides an overview of rodent research models, which vary in their pathophysiological alterations, ability to replicate behavioural symptoms, and response to pharmacological treatments. Given this heterogeneity, it remains challenging to determine which rodent model best represents ADHD or its different subtypes. Consequently, validating these models against contemporary medication therapies and testing candidate natural compounds as potential adjuvant treatments is essential. Additionally, combining models induced by neurotoxins, environmental substances, and genetic modifications may help evaluate potential interactions and their impact on ADHD development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.