Evidence map›Paper›PMID 40988025›Full record

ReviewInternational journal of emergency medicine2025

Review of current knowledge regarding usage of pre-hospital heart rate variability and complexity in triage and added value for predicting the need for life-saving interventions.

Christoffer B Hedegaard, Kasper Iversen, Fredrik Folke, Morten Lock-Hansen, Carolina Malta Hansen, Jannik Pallisgaard

Abstract readReview
In one paragraph

Review in International journal of emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christoffer B HedegaardDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. mikadohytten126@gmail.com.
Kasper IversenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Fredrik FolkeDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Morten Lock-HansenDepartment of Cardiology, The Capital Heart Center, Rigshospitalet, Copenhagen, Denmark.
Carolina Malta HansenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jannik PallisgaardPrivate Consultant Cardiologist, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimAnalysis of heart rate variability metrics has shown added accuracy in pre-hospital trauma triage. These metrics include heart rate variability (HRV), meaning oscillations in the time interval between heartbeats, and heart rate complexity (HRC), which assesses intricate patterns of heart rate over time. This review article evaluates current knowledge regarding HRV and HRC and prediction of a subsequent life-saving intervention (LSI), an intervention executed by trained medical personnel to prolong the life of the patient. Our primary focus was on pre-hospital patients and the utility of HRV and HRC when added to existing trauma triage scores or vital signs such as heart rate (HR). METHODE: A literature search was carried out by searching the MEDLINE database via the PubMed website for original research published in English from 2008 to 2023. The combinations of search terms applied yielded 18 original studies of which only six met our criteria. We included another study as it contributed original research beneficial to our article.

resultsThe studies showed a statistically significant increase in the ∆Area Under Curve (AUC) between 0.14 and 0.40 for predicting risk of LSI when adding the two heart rate variability metrics to existing trauma triage scores or vital signs such as HR. Calculation of HRV and/or HRC could be conducted using ECG recording hardware already accessible in most emergency pre-hospital settings with less ECG noise and therefore higher quality ECG data over time.

conclusionBoth HRV and HRC showed potential for increasing ∆AUC in predicting risk of LSI when added to existing risk triage scores. Calculation of HRV and HRC could potentially be conducted using a preexisting hardware in most emergency pre-hospital settings.

Identifiers

PMID40988025
PMCPMC12459062

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.