SynthesisBMC oral health2025
Impact of graphene-incorporated nanofillers on material properties and performance of polymers used for prosthodontic patients: a systematic review and meta-analysis.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Graphene and Related Materials: Properties and Applications in Dentistry.Materials (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGraphene has been successfully used for years in several applications. It had great potential for use in the medical field. Recently, incorporating graphene into dental biomaterials manufacturing has revolutionized prosthodontics. There is no clear data about the benefit and concentration of adding adding graphene or its derivatives into polymers used in prosthodontics. Accordingly, this review aimed to test the hypothesis that incorporating graphene or its derivatives into prosthodontic polymers, even at low concentrations, improves mechanical properties compared to conventional materials, without compromising biocompatibility.
methodsThe databases (PubMed, Web of Science, Cochrane Library and Willey) were searched based on the designed search strategy. The search strategy was developed using accessible terms, such as, 'graphene,' 'prosthodontic polymers,' 'PMMA,' 'mechanical properties,' and 'dental nanocomposites.' including medical search topic terms (MESH) where possible, in line with the PICO question. The search process did not include any filters for date or language. Quality assessments were undertaken in the included articles. Meta-analysis was calculated using the standardized mean difference as an effect size, considering the random effect model. Cochran Q and inconsistency I
resultsOut of 756 records from databases and other sources, only 22 articles were considered for data extraction according to the inclusion criteria. Eighteen studies were valid for meta-analysis, including seven material properties: flexural strength, impact strength, compressive strength, Shore D hardness, Shore A hardness, Vicker's hardness and surface roughness. Subgroup analysis, which relied on nanofiller concentration, showed enhanced outcomes at low concentrations. Low sensitivity and variable publication bias levels were recognized.
conclusionsWhile low-concentration graphene shows optimized prosthodontic nanocomposites' properties, high heterogeneity and methodological variability across studies preclude definitive clinical recommendations. Future research must prioritize standardized protocols and clinical validation.
trial registrationPROSPERO CRD42024522295.
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