Evidence map›Paper›PMID 40987917›Full record

ArticleArchives of gynecology and obstetrics2025

Transvaginal Natural orifice transluminal endoscopic hysterectomy vs. abdominal laparoscopic approach in real-life practices: a retrospective cohort study.

Ala Aiob, Yara Nakhleh Francis, Haya Hebi, Saaed Awwad, Susana Mustafa Mikhail, Avishalom Sharon, Inshirah Sgayer, Lior Lowenstein

Abstract readComparative Study
In one paragraph

Article in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ala Aiob *Department of Obstetrics and Gynecology, Galilee Medical Center, 89 Nahariya-Cabri, Nahariya, Israel. Ala.aiob@gmail.com.
Yara Nakhleh Francis *Department of Obstetrics and Gynecology, Galilee Medical Center, 89 Nahariya-Cabri, Nahariya, Israel.
Haya HebiDepartment of Obstetrics and Gynecology, Galilee Medical Center, 89 Nahariya-Cabri, Nahariya, Israel.
Saaed AwwadDepartment of Obstetrics and Gynecology, Galilee Medical Center, 89 Nahariya-Cabri, Nahariya, Israel.
Susana Mustafa MikhailDepartment of Obstetrics and Gynecology, Galilee Medical Center, 89 Nahariya-Cabri, Nahariya, Israel.
Avishalom SharonDepartment of Obstetrics and Gynecology, Galilee Medical Center, 89 Nahariya-Cabri, Nahariya, Israel.
Inshirah SgayerDepartment of Obstetrics and Gynecology, Galilee Medical Center, 89 Nahariya-Cabri, Nahariya, Israel.
Lior LowensteinDepartment of Obstetrics and Gynecology, Galilee Medical Center, 89 Nahariya-Cabri, Nahariya, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aims to retrospectively evaluate the surgical outcomes of total hysterectomy performed via Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) compared to laparoscopic hysterectomy (LAP) in treating benign gynecologic conditions in a real-world clinical setting.

methodsThis retrospective cohort study was conducted at Galilee Medical Center, Israel, between March 2021 and 2023. A total of 133 women were included in the study. The vNOTES group comprised 58 women, while 75 women underwent LAP. All women eligible for laparoscopic hysterectomy for benign conditions were offered the vNOTES approach. Exclusion criteria included prior pelvic radiation, active genital infections, rectovaginal endometriosis, or the need for oncogynecologic surgery related to malignancy.

resultsThe vNOTES group demonstrated significantly shorter operative times (69.5 vs. 117.4 min, p < 0.001) and anesthesia durations (102 vs. 146.3 min, p < 0.001), as well as reduced blood loss (108.6 mL vs. 237.9 mL, p < 0.001) compared to the LAP group. Postoperative pain, assessed by VAS scores, was significantly lower in the vNOTES group than in the LAP group (2.33 vs. 3.11, p = 0.013), with fewer requests for intravenous analgesics. No significant differences were observed between the groups in complication rates, conversion to laparotomy, or postoperative hospital stays.

conclusionThe vNOTES hysterectomy demonstrated shorter operative and anesthesia times, reduced blood loss, lower postoperative pain, and intravenous analgesic requirements compared to laparoscopic hysterectomy, without increasing complication rates. These findings suggest that vNOTES offers a viable, minimally invasive alternative to conventional laparoscopic hysterectomy for the treatment of benign gynecologic conditions. Further prospective studies are needed to assess long-term outcomes and the impact on quality of life.

Indexed as

HysterectomyLaparoscopyNatural Orifice Endoscopic SurgeryAdultBlood Loss, SurgicalFemaleHumansIsraelMiddle AgedOperative TimePostoperative PainRetrospective StudiesTreatment OutcomeVaginaMinimally invasive techniquesSurgical techniquesTransluminal surgeryVaginal surgery

Identifiers

PMID40987917
PMCPMC12589195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.