ArticleNature plants2025
Discovery of functional NLRs using expression level, high-throughput transformation and large-scale phenotyping.
Article in Nature plants, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Pathogenicity and virulence of the blast fungusVirulence · 2026Review
- No Cost of Resistance in Wheat Gene Stack Lines Containing 10 Stem Rust Resistance Transgenes.Plant biotechnology journal · 2026Article
- Engineering an Exo70 integrated domain of a barley NLR for improved blast resistance.The Plant cell · 2026Article
- The annotated blueprint: integrated functional genomic resources for a model tetraploid wheat Triticum turgidum cv Kronos.The New phytologist · 2026Article
- Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Large-scale plant genomic identification and analysis uncoverHorticulture research · 2026Article
- Improved reannotations of Aegilops umbellulata (PI 554389) genome and transcriptomics data provide candidates for leaf rust resistance for wheat improvement.Scientific reports · 2025Article
- The Annotated Blueprint: Integrated Functional Genomic Resources for a model Tetraploid WheatbioRxiv : the preprint server for biology · 2025Article
- Characterization and mapping of a rust resistance locus in the common bean landrace G19833.G3 (Bethesda, Md.) · 2025Article
- DaapNLRSeek, prediction, and evolution of resistance genes in polyploid sugarcane genomes.iScience · 2025Article
- A physical model links structure and function in the plant immune system.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A well-annotated genome of Apium graveolens var. dulce cv. Challenger, a celery with resistance to Fusarium oxysporum f. sp. apii race 2.The Plant journal : for cell and molecular biology · 2025Article
- The resistance awakens: Diversity at the DNA, RNA, and protein levels informs engineering of plant immune receptors from Arabidopsis to crops.The Plant cell · 2025Review
- It's Complicated: Why Are There So Few Commercially Successful Crop Varieties Engineered for Disease Resistance?Molecular plant pathology · 2025Review
- Pyramiding of transgenic immune receptors from primary and tertiary wheat gene pools improves powdery mildew resistance in the field.Journal of experimental botany · 2024Article
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Authors and funding
18 authors.
Funding
Abstract
Protecting crops from diseases is vital for the sustainable agricultural systems that are needed for food security. Introducing functional resistance genes to enhance the plant immune system is highly effective for disease resistance, but identifying new immune receptors is resource intensive. We observed that functional immune receptors of the nucleotide-binding domain leucine-rich repeat (NLR) class show a signature of high expression in uninfected plants across both monocot and dicot species. Here, by exploiting this signature combined with high-throughput transformation, we generated a wheat transgenic array of 995 NLRs from diverse grass species to identify new resistance genes for wheat. Confirming this proof of concept, we identified new resistance genes against the stem rust pathogen Puccinia graminis f. sp. tritici and the leaf rust pathogen Puccinia triticina, both major threats to wheat production. This pipeline facilitates the rapid identification of candidate NLRs and provides in planta gene validation of resistance. The accelerated discovery of new NLRs from a large gene pool of diverse and non-domesticated plant species will enhance the development of disease-resistant crops.
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