Evidence map›Paper›PMID 40987854›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Assessing the application potential of different species as obstructive sleep apnea models: a comparative analysis based on cranial CT anatomy.

Yiwei Feng, Weisong Cai, Xiaoping Ming, Xiong Chen

Erratum issuedAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Yiwei FengDepartment of Otorhinolaryngology, Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
Weisong CaiDepartment of Otorhinolaryngology, Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xiaoping MingDepartment of Otorhinolaryngology, Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xiong ChenDepartment of Otorhinolaryngology, Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China. zn_chenxiong@whu.edu.cn.ORCID http://orcid.org/0000-0002-0886-0190

Funding

Key Research and Development Project of Hubei Province 2022BCA040National Natural Science Foundation of China 82071033National Natural Science Foundation of China 82371135National Natural Science Foundation of China 82401343
6 · The paper itself

Abstract

purposeThe goal of this study was to compare the cranial anatomical characteristics of different animals to provide a scientific basis for the selection of obstructive sleep apnoea (OSA) animal models.

methodsWe analysed the computed tomography (CT) scan images of humans, Macaca, rabbits, mice, rats, and tree shrews; employed 3D reconstruction and measurement techniques to assess the morphological characteristics of the mandible, hyoid bone, and thyroid cartilage; normalized volumes of the tongue and soft palate, fat distribution, and volume and morphology of the airway in each species; and compared their similarity to the corresponding human structures.

resultsMacaca has the greatest similarity to humans in terms of skeletal structure, airway morphology, and fat distribution. With respect to skeletal structure and soft palate research, the anatomical features of tree shrews make them highly competitive candidates. Rabbits have a weak anterior neck area and a long soft palate and tongue base, thus forming a narrow supraglottic and glottic region; when the research target involves these areas, the use of a rabbit model may be more appropriate.

conclusionThese findings provide a solid scientific foundation for the selection and optimization of OSA animal models, which not only helps to deepen our understanding of the pathophysiological mechanisms of OSA but also promotes the development of new treatment methods.

Indexed as

Disease Models, AnimalSkullSleep Apnea, ObstructiveTomography, X-Ray ComputedAnimalsHumansHyoid BoneImaging, Three-DimensionalMandibleMicePalate, SoftRabbitsRatsSpecies SpecificityTongueTupaiidaeAnimal modelsComputed tomographyObstructive sleep apnoeaUpper airway

Identifiers

PMID40987854

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.