Evidence map›Paper›PMID 40987809›Full record

ArticleScientific reports2025

Dual ACE2 epitope-based biomimetic receptors for selective sensing of SARS-CoV variants.

Tiba Al-Dujaili, Sara Björk Sigurdardóttir, Verónica A Jiménez, Michele Larocca, Börje Sellergren

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tiba Al-DujailiDepartment of Biomedical Sciences and Biofilms-Research Center for Biointerfaces (BRCB), Faculty of Health and Society, Malmö University, 20506, Malmö, Sweden.
Sara Björk SigurdardóttirDepartment of Biomedical Sciences and Biofilms-Research Center for Biointerfaces (BRCB), Faculty of Health and Society, Malmö University, 20506, Malmö, Sweden.
Verónica A JiménezDepartamento de Ciencias Químicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Autopista Concepción-Talcahuano, 7100, Talcahuano, Chile.
Michele LaroccaDepartment of Biomedical Sciences and Biofilms-Research Center for Biointerfaces (BRCB), Faculty of Health and Society, Malmö University, 20506, Malmö, Sweden.
Börje SellergrenDepartment of Biomedical Sciences and Biofilms-Research Center for Biointerfaces (BRCB), Faculty of Health and Society, Malmö University, 20506, Malmö, Sweden. borje.sellergren@mau.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a combinatorial approach to design peptide-based biomimetic sensors for detecting β-type coronaviruses with high sensitivity and selectivity. We selected three peptide epitopes from key regions of the ACE2 receptor that are involved in viral binding to different variants and immobilized them individually or in binary combinations on gold sensor chips. Using Surface Plasmon Resonance (SPR), we found that single-epitope sensors displayed nanomolar dissociation constants to three RBD variants (SARS-CoV-2 Delta < SARS-CoV-2 Alpha < SARS-CoV-1) and a K

Indexed as

Angiotensin-Converting Enzyme 2Biosensing TechniquesCOVID-19EpitopesSARS-CoV-2Spike Glycoprotein, CoronavirusBiomimeticsHumansMolecular Dynamics SimulationProtein BindingSurface Plasmon ResonanceACE2 protein, humanAngiotensin-Converting Enzyme 2EpitopesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2ACE2-based sensorBiosensorCombinatorial detectionSARS-CoV-2SARS-CoV variantsSPR

Identifiers

PMID40987809
PMCPMC12457685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.