ArticleThe journal of obstetrics and gynaecology research2025
Iron metabolism study: The characteristics of iron metabolism in patients with ovarian endometriosis complicated with infertility.
Article in The journal of obstetrics and gynaecology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Iron metabolism study: The characteristics of iron metabolism in patients with ovarian endometriosis complicated with infertility.The journal of obstetrics and gynaecology research · 2025Article
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Abstract
objectivesThis study investigates iron metabolism characteristics in patients with ovarian endometriosis (EMs) and infertility.
methodsA case-control study was conducted involving 76 infertility patients treated at Baise People's Hospital from December 2023 to December 2024. Among them, 36 patients with ovarian EMs and infertility were included in the case group, whereas 40 infertile women without EMs constituted the control group. The indices of iron metabolism, including serum iron (SI), transferrin (TRF), soluble transferrin receptor (sTfR), unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC), and transferrin saturation (TS), were measured and compared between the two groups. Furthermore, the association between iron metabolism levels and the development and progression of EMs was systematically analyzed.
resultsThe SI level was significantly higher in the study group than in the control group (p < 0.01). Levels of TRF, UIBC, and TIBC were significantly lower in the study group compared to the control group (p < 0.001). No significant differences were observed in sTfR or TS between the two groups (p > 0.05). Receiver operating characteristic curve analysis demonstrated that the combined assessment of SI, TRF, UIBC, and TIBC provided statistically significant diagnostic accuracy for differentiating between the two groups, with corresponding p values less than 0.01.
conclusionAbnormal iron metabolism is present in patients with EMs and infertility. Excessive iron accumulation may exacerbate disease progression and influence reproductive prognosis. Modulating iron metabolism could potentially serve as a novel strategy to improve the condition of EMs and pregnancy outcomes.
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