Evidence map›Paper›PMID 40987727›Full record

ArticleBMJ open2025

Comparison of diagnostic yield and safety of three endobronchial ultrasound-guided transbronchial biopsy techniques in diagnosing patients with mediastinal/hilar lymphadenopathy: a protocol of multicentre randomised trial in China.

Ming-Ming Deng, Zhen Yang, Changhao Zhong, Ziwen Zheng, Run Tong, Guowu Zhou, Xuelian Li, Ling Zhao, Felix J F Herth, Gang Hou

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06262620 (The Comparison of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration, Mediastinal Cryobiopsy Via a Tunnel, and Forceps Biopsy Via a Tunnel in Diagnosing Mediastinal Lymphadenopathy), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06262620 narecruitingnot on this map

The Comparison of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration, Mediastinal Cryobiopsy Via a Tunnel, and Forceps Biopsy Via a Tunnel in Diagnosing Mediastinal Lymphadenopathy: a Multicenter Randomised Controlled Trial.

TypeinterventionalSponsorChina-Japan Friendship HospitalRan2024 to 2026Enrolled552ConditionsLymphadenopathy Hilar, Lymphadenopathy MediastinalArmsEBUS-TBNA, EBUS-TBMC via a tunnel, EBUS-TBFB via a tunnel
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ming-Ming Deng *National Centre for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Centre for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Zhen Yang *Department of Respiratory Medicine, Eighth Medical Centre of Chinese People's Liberation Army General Hospital, Beijing, China.
Changhao Zhong *Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, National Centre for Respiratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Ziwen Zheng *National Centre for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Centre for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.ORCID http://orcid.org/0000-0003-1711-6328
Run TongNational Centre for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Centre for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Guowu ZhouNational Centre for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Centre for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Xuelian LiDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning, China.
Ling ZhaoDepartment of Pathology, China-Japan Friendship Hospital, Beijing, China.
Felix J F HerthDepartment of Pneumology and Critical Care Medicine, Thoraxklinik, and Translational Lung Research Centre Heidelberg, University of Heidelberg, Heidelberg, Germany.
Gang HouNational Centre for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Centre for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China hougangcmu@163.com.ORCID http://orcid.org/0000-0003-3438-1764

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMediastinal and/or hilar lymphadenopathy (MHL) is increasingly identified owing to various underlying conditions. Minimally invasive biopsy techniques, including endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), transbronchial mediastinal cryobiopsy (TBMC) and transbronchial forceps biopsy (TBFB), are common diagnosis tools. However, their safety and diagnostic efficiency remain unclear. This trial aims to compare the diagnostic yield and safety of these three techniques. METHODS AND ANALYSIS: This study is a three-arm, parallel-design, randomised controlled trial involving 972 adult patients with MHL recruited from multiple medical centres. Participants will be randomly assigned to the EBUS-TBNA, TBMC via a tunnel or TBFB via a tunnel group. The primary outcome is diagnostic yield, and the secondary outcomes include diagnostic sensitivity, sample quality and procedure-related complications. Statistical analyses will be conducted using the appropriate methods. An independent sample χ² test will be used to test the differences in the diagnostic yield and incidence of procedure-related complications. ETHICS AND DISSEMINATION: Ethics approval was obtained from the China-Japan Friendship Hospital Ethics Committee (2022-KY-194).Written informed consent will be obtained from all patients or their guardians before their enrolment in the study. This study will be conducted per the principles established in the Declaration of Helsinki and the International Council for Harmonisation Guidelines for Good Clinical Practice. TRIAL REGISTRATION NUMBER: www. CLINICALTRIALS: gov (NCT06262620).

Indexed as

BronchoscopyEndoscopic Ultrasound-Guided Fine Needle AspirationLymphadenopathyMediastinal DiseasesAdultChinaFemaleHumansImage-Guided BiopsyMaleMediastinumMiddle AgedMulticenter Studies as TopicRandomized Controlled Trials as TopicBronchoscopyClinical ProtocolsClinical TrialRandomized Controlled Trial

Identifiers

PMID40987727
PMCPMC12458882

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.