Evidence map›Paper›PMID 40986941›Full record

ArticleParkinsonism & related disorders2025

The effect of subthalamic nucleus deep brain stimulation on speech metrics in Parkinson's disease.

Goun Je, Pranav Akella, Kevin B Wilkins, Helen M Bronte-Stewart

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Article in Parkinsonism & related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Goun JeDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States; Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States.
Pranav AkellaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Kevin B WilkinsDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
Helen M Bronte-StewartDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, United States. Electronic address: hbs@stanford.edu.

Funding

Bilateral Closed Loop Deep Brain Stimulation for Freezing of Gait using Neural and Kinematic FeedbackUH3NS107709 · NINDS · STANFORD UNIVERSITY · PI BRONTE-STEWART, HELEN · 2019 to 2023
$6.1M
Neurostimulation of the Nucleus Basalis of Meynert for the Cognitive-Motor Syndrome in Parkinson's DiseaseUH3NS128150 · NINDS · STANFORD UNIVERSITY · PI Helen Bronte-Stewart · 2024 to 2026
$3.6M
NINDS NIH HHS UH3 NS107709NINDS NIH HHS UH3 NS128150
6 · The paper itself

Abstract

backgroundSpeech impairment frequently occurs in Parkinson's disease (PD). The sequence effect, progressive deterioration in speed or amplitude of ongoing movement, is unique to PD and does not respond well to dopaminergic therapy. While subthalamic nucleus deep brain stimulation (STN DBS) can improve various motor symptoms in PD, its impact on speech and the speech sequence effect remains unclear. Here, we investigated the effects of STN DBS on speech metrics including the sequence effect in people with PD.

methodsFifteen individuals with PD who underwent bilateral STN DBS surgery participated in this study. We utilized the sustained phonation (SP) test and the diadochokinetic (DDK) test, which were performed under both OFF and ON stimulation conditions. Primary outcome measures included total SP duration, mean intensity, DDK rates, and the speech sequence effect.

resultsSTN DBS significantly improved the duration of SP without altering mean intensity. It also improved the rate of DDK syllable production for /pa/. However, it did not significantly change the speech sequence effect.

conclusionsThese findings indicate that while STN DBS can enhance certain speech parameters, it does not significantly mitigate the speech sequence effect. Further studies incorporating more comprehensive and functional speech assessment are needed to better understand the broader impact of DBS on speech and guide personalized treatment strategies for speech impairment in PD.

Indexed as

Deep Brain StimulationOutcome Assessment, Health CareParkinson DiseaseSpeechSpeech DisordersSubthalamic NucleusAgedFemaleHumansMaleMiddle AgedDeep brain stimulationDiadochokinetic testParkinson's diseaseSequence effectspeech impairmentSustained phonation

Identifiers

PMID40986941
PMCPMC12582248

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.