Evidence map›Paper›PMID 40986713›Full record

SynthesisJBRA assisted reproduction2025

Bisphenol A and human fertility: a systematic review.

Carolina Paz Mohamad Isa, Gabriela Barella Schmidt, Renata Guerreiro de Jesus, Joselaine Sturmer, Júlia Prauchner de Castilhos, Laura Randon Chapochnicoff, Victória Campos Dornelles, Marta Ribeiro Hentschke, Alvaro Petracco, Mariangela Badalotti

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in JBRA assisted reproduction, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carolina Paz Mohamad IsaPontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Gabriela Barella SchmidtFederal University of Rio Grande do Sul, Porto Alegre, Brazil.
Renata Guerreiro de JesusPontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Joselaine SturmerFertilitat - Medical Reproductive Center, Porto Alegre, Brazil.
Júlia Prauchner de CastilhosPontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Laura Randon ChapochnicoffPontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Victória Campos DornellesPontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Marta Ribeiro HentschkePontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Alvaro PetraccoFertilitat - Medical Reproductive Center, Porto Alegre, Brazil.
Mariangela BadalottiPontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering the significant exposure to the synthetic compound bisphenol A (BPA), present in a wide range of materials in our daily lives, this article discusses a possible correlation between this substance and human fertility through a bibliographic review. In the context of growing evidence that BPA impacts the fertility of women and men of reproductive age, the reviewed articles suggest that exposure to this agent may affect ovarian reserve parameters in women. In pregnant women, it may cause fetal malformations. BPA has also been linked to an increase in spontaneous abortions and premature births. Additionally, it can cause hormonal disruptions, affect folliculogenesis, and worsen ovarian response in assisted reproduction, as well as lead to lower estradiol concentrations, reduced fertilization rates, and higher implantation failure. In men of reproductive age, BPA may decrease sperm production, potentially contributing to testicular dysgenesis syndrome and cryptorchidism. However, further studies are still required to better understand the diverse and complex mechanisms through which BPA affects key reproductive functions.

Indexed as

Benzhydryl CompoundsEndocrine DisruptorsFertilityPhenolsBisphenol A CompoundsFemaleHumansMalePregnancyBenzhydryl Compoundsbisphenol ABisphenol A CompoundsEndocrine DisruptorsPhenolsassisted reproductionbisphenol A (BPA)endocrine disruptorshuman fertilitysperm production

Identifiers

PMID40986713
PMCPMC12694960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.