Observational studyPloS one2025
Prognostic value of D-dimer in treatment and follow up for patients who underwent radiotherapy in advanced lung cancer.
Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
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Authors and funding
2 authors.
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Abstract
backgroundLung carcinma, a serious disease commonly recognized at advanced stages and has less favorable outcomes to treatments. This research examines the association between D-dimer values and clinical variables in patients diagnosed with advanced lung cancer, with a focus on their prognostic significance and radiotherapy related outcomes.
methodsThis retrospective observational descriptive cohort study, including 142 patients with lung cancer. Aa comprehensive analysis, was conducted, including demographic variables,clinical staging, pathology, laboratuary tests, and D-dimer levels measured both before and after the administration of radiotherapy.
resultsThe findings indicated that high pre-RT D-dimer concentrations were significantly assoccciated with advanced stages of disease, worse response of radiotherapy, Eastern Cooperative Oncology Group performance status, and decreased survival outcomes. Radiotherapy response also affects to survival rates with D-dimer values. The findings from both univariate and multivariable survival analyses demonstrated that lower concentrations of D-dimer correlated with better response of radiotherapy, extended overall survival and progression free survival (p: < 0.001).
conclusionThese results illustrate the significant role of D-dimer as a valuable biomarker for assessing tumor burden and guiding radiotherapy and other treatment strategies in lung cancer, thereby necessitating further inquiry to evaluate its clinical implications.
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