Evidence map›Paper›PMID 40986491›Full record

ArticleJournal of patient safety2025

Understanding Clinical Decision Support Failures in Pediatric Intensive Care Units via Applied Systems Safety Engineering and Human Factors Problem Analysis: Insights From the DISCOVER Learning Lab.

Matthew Zackoff, Anabel Graciela, Kelly Collins, Daniel Loeb, Andrea Meisman, Kyesha James, Jose Generoso, Karina Ortega, Bain Butcher, Christina Cifra and 2 more

Abstract read
In one paragraph

Article in Journal of patient safety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthew ZackoffDivision of Critical Care Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine.
Anabel Graciela
Kelly CollinsDivision of Critical Care Medicine.
Daniel LoebDivision of Critical Care Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine.
Andrea MeismanDivision of Critical Care Medicine.
Kyesha JamesDivision of Critical Care Medicine.
Jose GenerosoDivision of Critical Care Medicine.
Karina OrtegaDivision of Critical Care Medicine.
Bain ButcherCollege of Medicine and School of Art, University of Cincinnati, Cincinnati, OH.
Christina CifraDivision of Medical Critical Care, Boston Department of Pediatrics, Children's Hospital, Harvard Medical School, Boston, MA.
Colleen BadkeDivision of Critical Care Medicine, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Illinois.
Maya DewanDivision of Critical Care Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine.ORCID 0000-0002-9966-3845

Funding

AHRQ HHS R18 HS029626
6 · The paper itself

Abstract

objectivesChildren receiving care in pediatric intensive care units (PICUs) are vulnerable to decompensation and diagnostic error due to the complex and dynamic nature of pediatric critical illness. In the PICU, the few clinical decision support (CDS) tools that have been implemented to support diagnostic accuracy (i.e., the ability to detect the presence of a condition) have not led to an increase in clinician adoption of desired practices nor demonstrated clear clinical benefit.

methodsThe DISCOVER Learning Lab analyzed workflow and failure modes in diagnosing and managing clinical decompensation in the PICU, using systems safety engineering and human factors to examine intersections with established CDS. Methods employed included qualitative interviews, workflow mapping, immersive virtual reality (VR) systems testing via a digital twin environment, and a failure modes effect analysis.

resultsWorkflow mapping and qualitative interviews revealed barriers to communication, workflow inefficiencies, and limited access to up-to-date clinical information during critical events in the PICU. The immersive VR systems testing elucidated how PICU staff members currently interact with CDS tools and how various tools could better integrate into or influence clinical workflows. Critical failure modes were identified with corresponding opportunity areas for intervention.

conclusionsThe application of a systems safety engineering and human factors approach to problem analysis, partnered with novel use of immersive VR and digital twin technology, led to valuable insights into common failure modes and potential opportunity areas to improve diagnostic accuracy and care delivery in a quaternary referral center PICU.

Indexed as

Decision Support Systems, ClinicalErgonomicsIntensive Care Units, PediatricPatient SafetyChildHealthcare Failure Mode and Effect AnalysisHumansInterviews as TopicVirtual RealityWorkflowclinical decision supporthuman factorspediatric intensive care unitsystems safety engineeringvirtual reality

Identifiers

PMID40986491
PMCPMC12453092

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.