Evidence map›Paper›PMID 40986427›Full record

ArticleEuropean heart journal2025

Interleukin-17 receptor-A signalling: atheroprotective role in JAK2 clonal haematopoiesis.

Kun Zhao, Cheng-Chieh Hsu, Yash Pershad, Caitlyn Vlasschaert, Robert W Corty, Nan Wang, Jonathan Brett Heimlich, Alan R Tall, Alexander G Bick

Abstract read
In one paragraph

Article in European heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Genetic factors contributing to atherosclerosis.Current opinion in cardiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kun ZhaoDepartment of Medicine, Vanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232, USA.ORCID 0000-0002-2811-4419
Cheng-Chieh HsuDivision of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA.ORCID 0000-0002-3423-7159
Yash PershadDepartment of Medicine, Vanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232, USA.ORCID 0000-0002-2282-1403
Caitlyn VlasschaertDepartment of Medicine, Queen's University, 94 Stuart Street, Kingston, Ontario K7L 3N6, Canada.ORCID 0009-0003-8466-7602
Robert W CortyDepartment of Medicine, Vanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232, USA.ORCID 0000-0002-6787-9051
Nan WangDivision of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA.
Jonathan Brett HeimlichDepartment of Medicine, Vanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232, USA.ORCID 0000-0003-2812-5326
Alan R TallDivision of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA.ORCID 0000-0002-7708-2417
Alexander G BickDepartment of Medicine, Vanderbilt University Medical Center, 2200 Pierce Avenue, Nashville, TN 37232, USA.ORCID 0000-0001-5824-9595

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Pharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4M
Understanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C. · 2015 to 2019
$13.0M
The Genetic Epemiology of Multiple SclerosisR01NS032830 · NINDS · VANDERBILT UNIVERSITY · PI HAINES, JONATHAN L · 1995 to 2010
$8.9M
Epidemiologic Architecture for Genes Linked to Environment (EAGLE)U01HG004798 · NHGRI · VANDERBILT UNIVERSITY · PI CRAWFORD, DANA C · 2008 to 2013
$8.8M
VESPA: Vanderbilt Electronic Systems for Pharmacogenomic AssessmentRC2GM092618 · NIGMS · VANDERBILT UNIVERSITY · PI DENNY, JOSHUA C., RODEN, DAN M · 2009 to 2010
$6.4M
Vanderbilt Genome Electronic Records ProjectU01HG006378 · NHGRI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2011 to 2014
$4.0M
Clonal hematopoiesis, inflammasomes and atherosclerosisR01HL155431 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAN richard TALL · 2021 to 2026
$3.7M
Understanding the genetic risk underlying racial disparities in uterine fibroids - Diversity SupplementR01HD074711 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VELEZ EDWARDS, DIGNA R · 2013 to 2017
$2.9M
Alliance for Genomic DiscoveryLeducq Foundation TNE-18CVD04NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006378NHLBI NIH HHS R01 HL155431NHLBI NIH HHS U19 HL065962NICHD NIH HHS R01 HD074711NIGMS NIH HHS P50 GM115305NIGMS NIH HHS RC2 GM092618NIGMS NIH HHS T32 GM007347NIH HHS DP5 OD029586NIH HHS DP5OD029586NIH HHS HL155431NIH HHS P50GM115305NIH HHS R01HD074711NIH HHS R01NS032830NIH HHS RC2GM092618NIH HHS S10 OD017985NIH HHS S10OD017985NIH HHS S10 OD025092NIH HHS S10OD025092NIH HHS S10RR025141NIH HHS T32GM007347NIH HHS U01HG004798NIH HHS U01HG006378NIH HHS U19HL065962NIH HHS UL1RR024975NIH HHS UL1TR000445NIH HHS UL1TR002243NINDS NIH HHS R01 NS032830
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AtherosclerosisClonal haematopoiesisGenetic modifiersInterleukin-17 receptor-AJAK2

Identifiers

PMID40986427
PMCPMC12718686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.