Evidence map›Paper›PMID 40986421›Full record

SynthesisInterdisciplinary cardiovascular and thoracic surgery2025

A Systematic Analysis of Coronary to Pulmonary Artery Fistula and Its Associated Aneurysm in Adults.

Chaoneng Wu, Shayne Joseph, Rakesh Devireddy, Marco Kaldas, Maxim Zlatopolsky, Omar Qaqish, Yunguo C Gong, Sonela Blaceri, Chadi Saad, William E Harder and 3 more

Abstract readSystematic Review
In one paragraph

Synthesis in Interdisciplinary cardiovascular and thoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chaoneng WuInternal Medicine Department, Garden City Hospital, Michigan State University, Garden City, MI 48135, United States.ORCID 0009-0007-7251-8094
Shayne JosephInternal Medicine Department, Garden City Hospital, Michigan State University, Garden City, MI 48135, United States.
Rakesh DevireddyCardiology Department, Garden City Hospital, Michigan State University, Garden City, MI 48135, United States.
Marco KaldasInternal Medicine Department, Garden City Hospital, Michigan State University, Garden City, MI 48135, United States.
Maxim ZlatopolskyCardiology Department, Garden City Hospital, Michigan State University, Garden City, MI 48135, United States.
Omar QaqishCardiology Department, Henry Ford Warren Medical Center, Warren, MI 48093, United States.
Yunguo C GongInternal Medicine Department, Garden City Hospital, Michigan State University, Garden City, MI 48135, United States.
Sonela BlaceriCardiology Department, Garden City Hospital, Michigan State University, Garden City, MI 48135, United States.
Chadi SaadNephrology Department, Garden City Hospital, Michigan State University, Garden City, MI 48135, United States.
William E HarderCardiology Department, Garden City Hospital, Michigan State University, Garden City, MI 48135, United States.
Fadi A SaabCardiology Department, Garden City Hospital, Michigan State University, Garden City, MI 48135, United States.
Sujata KambhatlaInternal Medicine Department, Garden City Hospital, Michigan State University, Garden City, MI 48135, United States.
Ashok KondurCardiology Department, Garden City Hospital, Michigan State University, Garden City, MI 48135, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe conducted a systematic review to evaluate the clinical features, diagnosis, and treatment of coronary artery to pulmonary artery fistula (CPAF) and its associated aneurysms.

methodsOur search encompassed MEDLINE/PubMed, Scopus, Google Scholar, and the Cochrane Collaboration Database from 1970 to 2025.

resultsA total of 461 cases were analysed. The volume of publications steadily increased after 2010. The left anterior descending coronary artery was the most common site of origin for CPAF. A total of 457 cases underwent coronary angiography confirming CPAF, with computed tomography coronary angiography being the most frequently used non-invasive imaging modality (190 cases, 41.2%). Stress tests were conducted in 78 cases (16.9%), revealing a coronary steal phenomenon associated with CPAF. Particularly, when comparing aneurysm CPAF to non-aneurysm CPAF, we found that older age is an independent risk factor for developing an aneurysm. For interventions, the symptomatic patients were more likely to close the fistula. We identified that 218 cases (49.7%) underwent surgical treatment, while 121 cases (27.6%) received percutaneous embolization. There were 8 reported deaths, resulting in a mortality rate of 1.8%.

conclusionsThe clinical presentations of CPAF are often non-diagnostic. Computed tomography coronary angiography is the preferred method for visualizing the fistulas and their surrounding structures. Surgical treatment is beneficial in cases of aneurysm CPAF or with other surgical indications. Transcatheter closure of CPAF may be considered for selected individuals with favourable anatomy (PROSPERO Number CRD42025643603). CLINICAL REGISTRATION NUMBER: PROSPERO Number CRD42025643603.

Indexed as

Arterio-Arterial FistulaCoronary AneurysmCoronary Vessel AnomaliesPulmonary ArteryAdultAgedCoronary AngiographyEmbolization, TherapeuticFemaleHumansMaleMiddle AgedRisk FactorsTreatment Outcomeadultsaneurysmcoronary artery to pulmonary artery fistula (CPAF)systematic review

Identifiers

PMID40986421
PMCPMC12456278

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.