Evidence map›Paper›PMID 40986368›Full record

ReviewExperimental physiology2026

Exercise prehabilitation for brain health and sensory-cognitive function: Mechanistic insights into brain-body interactions.

Helen E Nuttall, Daren Subar, Christopher J Gaffney

Abstract readReview
In one paragraph

Review in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Helen E NuttallDepartment of Psychology, Lancaster University, Bailrigg, UK.ORCID https://orcid.org/0000-0001-8497-5603
Daren SubarEast Lancashire Hospitals Trust, Blackburn, UK.
Christopher J GaffneyLancaster Medical School, Lancaster University, Bailrigg, UK.ORCID https://orcid.org/0000-0001-7990-2792

Funding

North West Cancer Research AR2024.07GAFFNEYNorth West Cancer Research and Rosemere Cancer Foundation NWCRRCC2024.01NUTTALL
6 · The paper itself

Abstract

This mini review article presents a novel hypothesis for extending exercise prehabilitation into the domains of brain health and cognition. Whilst prehabilitation has been gaining popularity in cancer treatment, conferring significant positive benefits to numerous physiological indicators, including post-operative infection and hospital length of stay, the benefits to patients' brain health and cognition are underexplored. There lies a timely and exciting opportunity in expanding prehabilitation to target neural and sensory dysfunction in cancer patients. We review data from healthy adults on the benefits of exercise to brain structure and function, and cognitive and sensory domains. Finally, we review how exercise could improve brain health, as well as sensory systems of the body, which are often negatively affected by cancer and associated treatment. We also outline further physiological contexts outside of cancer in which prehabilitation could also benefit brain health. Through this synthesis, we seek to inspire novel research into prehabilitation and brain health to further improve patient health and wellbeing.

Indexed as

BrainCognitionExercisePreoperative ExerciseSensationHumansbraincognitionexercise physiologyneuroscienceprehabilitationsensory input

Identifiers

PMID40986368
PMCPMC13140221

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.