ArticleProceedings of the National Academy of Sciences of the United States of America2025
ALKBH5 demethylates the m
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
–field-weighted citation impact
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Who cites it
12 citing papers in PubMed.
- Chlorogenic acid attenuates TBI-induced neuroinflammation by suppressing cGAS-STING signaling.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Lactylation and N6-Methyladenosine RNA modification in neuropsychiatric sequelae after intracerebral hemorrhage: a hypothesis-generating metabolic-glial-circuit framework.Molecular biology reports · 2026Review
- Targeting mNature communications · 2026Article
- mNature reviews. Neuroscience · 2026Review
- Epigenetic mechanisms in traumatic brain injury: a focus on astrocytes and therapeutic implications.Journal of neuroinflammation · 2026Review
- Targeted biohybrid nanoplatform for spinal cord injury treatment: Restoring microglial mitophagy and alleviating oxidative stress.Materials today. Bio · 2026Article
- Responsive nanoparticles modulating microglia lactate transport alleviate M1-type polarization and neuroinflammation for brain injury therapy.Journal of nanobiotechnology · 2026Article
- The N6-Methyladenosine RNA Demethylase AlkB Homolog 5 (ALKBH5) in Metabolic Diseases: Molecular Mechanisms and Pharmacological Implications-A Review.Biomolecules · 2026Review
- Cell-Type-Specific WTAP and ALKBH5-Mediated mCNS neuroscience & therapeutics · 2026Article
- Multicellular Exosomes as Therapeutic Modulators of Neuroinflammation: Mechanisms and Clinical Prospects.International journal of nanomedicine · 2026Review
- mFrontiers in immunology · 2026Review
- ALKBH5 demethylates the mProceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Lin Cai *Department of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Yuqing Liang *Department of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.ORCID 0009-0004-7969-1648
Xiaoyu Li *Department of Neurology, Zhongshan Hospital, Laboratory Animal Center, Ministry of Education Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China.ORCID 0000-0001-5156-8518
Runxi FuDepartment of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Institute for Pediatric Research, Shanghai 200092, China.
Xingyu NiuDepartment of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Yuxiao JinDepartment of Neurology, Zhongshan Hospital, Laboratory Animal Center, Ministry of Education Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China.ORCID 0000-0001-9527-8029
Yuxin LiNational Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, Ministry of Education Frontiers Center for Brain Science, Ministry of Education Innovative Center for New Drug Development of Immune Inflammatory Diseases, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai 200032, China.
Yuheng ZhangNational Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, Ministry of Education Frontiers Center for Brain Science, Ministry of Education Innovative Center for New Drug Development of Immune Inflammatory Diseases, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai 200032, China.
Pei OuyangNational Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, Ministry of Education Frontiers Center for Brain Science, Ministry of Education Innovative Center for New Drug Development of Immune Inflammatory Diseases, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai 200032, China.
Chen WangDepartment of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Qiuyuan GongDepartment of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Yang YangDepartment of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Lai WeiDepartment of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Yao JingDepartment of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Dianxu YangDepartment of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Zhiming XuDepartment of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Fang YuanDepartment of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Jun DingDepartment of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Hao ChenDepartment of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Bo PengNational Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, Ministry of Education Frontiers Center for Brain Science, Ministry of Education Innovative Center for New Drug Development of Immune Inflammatory Diseases, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai 200032, China.ORCID 0000-0003-4183-5939
Yanxia RaoDepartment of Neurology, Zhongshan Hospital, Laboratory Animal Center, Ministry of Education Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China.ORCID 0000-0001-5292-2056
Hengli TianDepartment of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Funding
MOST | National Natural Science Foundation of China (NSFC) 32170958MOST | National Natural Science Foundation of China (NSFC) 82171373MOST | National Natural Science Foundation of China (NSFC) 82301557
Abstract
Microglia/macrophage-induced neuroinflammation plays a crucial role in the progression of traumatic brain injury (TBI). However, the involvement of N6-methyladenosine (m
Indexed as
AdenosineAlkB Homolog 5, RNA DemethylaseBrain InjuriesBrain Injuries, TraumaticMacrophagesMicrogliaNeuroinflammatory DiseasesSuppressor of Cytokine Signaling 3 ProteinAnimalsDemethylationMaleMiceMice, Inbred C57BLSignal TransductionSTAT3 Transcription FactorAdenosineAlkB Homolog 5, RNA DemethylaseN-methyladenosineSocs3 protein, mouseSTAT3 Transcription FactorSuppressor of Cytokine Signaling 3 ProteinALKBH5microgliaN6-methyladenosineneuroinflammationSOCS3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.