Evidence map›Paper›PMID 40986346›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Muscle-specific increased expression of

Felipe de Souza Leite, Matthias R Lambert, Tracy Yuanfan Zhang, James R Conner, Joao A Paulo, Sheldon Furtado Oliveira, Sanjukta Guha Thakurta, Jennifer Bowles, Emanuela Gussoni, Steven P Gygi and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Muscle-specific increased expression ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Felipe de Souza Leite *Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0003-2493-8872
Matthias R Lambert *Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115.
Tracy Yuanfan Zhang *Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115.
James R ConnerDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115.
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-4291-413X
Sheldon Furtado OliveiraDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115.
Sanjukta Guha ThakurtaDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115.
Jennifer BowlesDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115.ORCID 0009-0007-5308-3101
Emanuela GussoniDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0002-9915-3677
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-7626-0034
Jeffrey J WidrickDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115.
Louis M KunkelDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0001-6126-0242

Funding

Modulation of Jagged1/Pitpna in DMD as a means of therapyR01AR064300 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI KUNKEL, LOUIS M · 2014 to 2023
$3.9M
A new multi-pathway kinase activity assay applied to compound library screening in cancer biologyR00CA273170 · NCI · UNIVERSITY OF VIRGINIA · PI ZHANG, TIAN · 2023 to 2025
$747k
Unveiling the molecular mechanisms in TPM3-related myopathy and therapiesK99AR080197 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI LAMBERT, MATTHIAS · 2022 to 2023
$212k
American Heart Association (AHA) AHA18POST34070039BCM | Intellectual and Developmental Disabilities Research Center (IDDRC) P50HD105351Bernard F. and Alva B. Gimbel Foundation (Bernard F. and Alva B. Gimbel Foundation, Inc.) NAConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 404161/2019-7Defeat Duchenne Canada NAFrench Muscular Dystrophy Association (AFM) 21904HHS | NIH | National Cancer Institute (NCI) R00CA273170HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) K99AR080197HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR064300Muscular Dystrophy Association (MDA) 10.55762/pc.gr.157029Muscular Dystrophy Association (MDA) https://doi.org/10.55762/MDA.1291397.pc.gr.198128NIAMS NIH HHS R01 AR064300NIH HHS gm067945Office of Faculty Development at Boston Children's Hospital NA
6 · The paper itself

Abstract

Therapeutic strategies for Duchenne muscular dystrophy (DMD) will likely require complementary approaches. One possibility is to explore genetic modifiers that improve muscle regeneration and function. The beneficial effects of the overexpression of Jagged-1 were described in escaper golden retriever muscular dystrophy (GRMD) dogs that had a near-normal life and validated in dystrophin-deficient zebrafish. To clarify the underlying biology of

Indexed as

Calcium-Binding ProteinsDystrophinIntercellular Signaling Peptides and ProteinsMembrane ProteinsMuscle, SkeletalMuscular Dystrophy, DuchenneAnimalsHumansJagged-1 ProteinMiceMice, Inbred mdxMice, TransgenicPhenotypeSerrate-Jagged ProteinsCalcium-Binding ProteinsDystrophinIntercellular Signaling Peptides and ProteinsJAG1 protein, humanJag1 protein, mouseJagged-1 ProteinMembrane ProteinsSerrate-Jagged ProteinsDuchenne muscular dystrophygenetic modifierJagged-1mouse modelphysiology

Identifiers

PMID40986346
PMCPMC12501121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.