Evidence map›Paper›PMID 40986343›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Structural and functional analysis of the

Adam J Fountain, Jan Böhning, Stephen H McLaughlin, Tomos E Morgan, Paul H Edelstein, Mark Troll, Meindert H Lamers, Tanmay A M Bharat, Ben F Luisi, Lalita Ramakrishnan

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Structural elucidation of the hexameric MmpS4-MmpL4 complex frombioRxiv : the preprint server for biology · 2026
    Article
  2. Frontiers in cellular and infection microbiology · 2026
    Article
  3. Article
  4. Structural and functional analysis of theProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Adam J FountainMedical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0003-4232-3791
Jan BöhningMedical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Stephen H McLaughlinMedical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0001-9135-6253
Tomos E MorganMedical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Paul H EdelsteinMedical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0002-4069-5279
Mark TrollMedical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Meindert H LamersDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands.
Tanmay A M BharatMedical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0002-0168-0277
Ben F LuisiDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.ORCID 0000-0003-1144-9877
Lalita RamakrishnanMedical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0003-0692-5533

Funding

Host Responses to Mycobacterium Infection in ZebrafishR01AI054503 · NIAID · UNIVERSITY OF WASHINGTON · PI LALITA RAMAKRISHNAN · 2003 to 2026
$4.4M
EC | European Research Council (ERC) 742210HHS | National Institutes of Health (NIH) R01AI054503NIAID NIH HHS R01 AI054503UK Research and Innovation (UKRI) MC_UP_1201/31Wellcome TrustWellcome Trust (WT) 222451/Z/21/ZWellcome Trust (WT) 223103/Z/21/ZWellcome Trust (WT) 225317/Z/22/Z
6 · The paper itself

Abstract

Bedaquiline, an antitubercular drug that targets ATP-synthase, is a key component of a new oral drug regimen that has revolutionized the treatment of multidrug-resistant tuberculosis. Clinical bedaquiline resistance in

Indexed as

Antitubercular AgentsBacterial ProteinsDiarylquinolinesDrug Resistance, BacterialMembrane Transport ProteinsMycobacterium tuberculosisCryoelectron MicroscopyModels, MolecularMutationAntitubercular AgentsBacterial ProteinsbedaquilineDiarylquinolinesMembrane Transport Proteinsbedaquilinedrug resistanceMmpS5L5 drug efflux pumpMycobacterium tuberculosis

Identifiers

PMID40986343
PMCPMC12501195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.