Evidence map›Paper›PMID 40986342›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Genetic dissection of nonconventional introns reveals codominant noncanonical splicing code in

Toshihisa Nomura, June-Sik Kim, Osamu Iwata, Koji Yamada, Kohei Atsuji, Yukiko Uehara-Yamaguchi, Takuhiro Yoshida, Komaki Inoue, Kotaro Takahagi, Tetsuya Sakurai and 5 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Genetic dissection of nonconventional introns reveals codominant noncanonical splicing code inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Toshihisa Nomura *RIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.
June-Sik Kim *RIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.ORCID 0000-0002-4703-609X
Osamu IwataEuglena Co., Ltd., Tokyo 108-0014, Japan.
Koji YamadaRIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovative Hub, Yokohama 230-0045, Japan.ORCID 0000-0002-2049-0882
Kohei AtsujiEuglena Co., Ltd., Tokyo 108-0014, Japan.
Yukiko Uehara-YamaguchiRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.
Takuhiro YoshidaRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.
Komaki InoueRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.
Kotaro TakahagiRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.
Tetsuya SakuraiRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.
Kazuo ShinozakiRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.
Takuro ItoDepartment of Creative Engineering, National Institute of Technology, Tsuruoka College, Tsuruoka 997-8511, Japan.
Kengo SuzukiRIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovative Hub, Yokohama 230-0045, Japan.
Keisuke GodaDepartment of Chemistry, University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0001-6302-6038
Keiichi MochidaRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.ORCID 0000-0003-1299-0024

Funding

MEXT | Japan Science and Technology Agency (JST) JPMJGX23B0MEXT | Japan Science and Technology Agency (JST) JPMJOP1832MEXT | Japan Society for the Promotion of Science (JSPS) JP21K05511MEXT | JST | Science and Technology Research Partnership for Sustainable Development (SATREPS) JPMJSA2204
6 · The paper itself

Abstract

Pre-mRNA splicing is essential for eukaryotic gene expression and is achieved through the accurate recognition of exon-intron boundaries. Although nonconventional introns, which do not follow the conventional GT-AG splicing rule, have been identified in several species, these introns are typically rare in any given genome. Here, we demonstrate the widespread occurrence of nonconventional introns (71.8% of all introns) in the

Indexed as

EuglenaIntronsRNA SplicingDNA, ProtozoanEuglena gracilisExonsGene EditingGenome, ProtozoanWhole Genome SequencingDNA, ProtozoanEuglenagenome editingnonconventional intronsynthetic intron

Identifiers

PMID40986342
PMCPMC12501133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.