Evidence map›Paper›PMID 40986285›Full record

ArticleChemPlusChem2025

Cyanostyryl-Guanidiniocarbonyl-Pyrrole Amphiphiles: From Aggregation-Induced Emission to Photodimerization, Self-Assembly, and Bioimaging.

Kevin Rudolph, Lea Höfmann, Sidharth Thulaseedharan Nair Sailaja, Alexander Höing, Johannes Koch, Nina Schulze, Elisabeth Verheggen, Felix C Niemeyer, Florian Uteschil, Shirley K Knauer and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemPlusChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kevin RudolphFaculty of Chemistry (Organic Chemistry), Center of Medical Biotechnology (ZMB) and Center for Nanointegration (CENIDE), University of Duisburg-Essen, Universitätsstraße 7, 45117, Essen, Germany.
Lea HöfmannFaculty of Chemistry (Organic Chemistry), Center of Medical Biotechnology (ZMB) and Center for Nanointegration (CENIDE), University of Duisburg-Essen, Universitätsstraße 7, 45117, Essen, Germany.ORCID 0009-0002-2162-6494
Sidharth Thulaseedharan Nair SailajaFaculty of Chemistry (Organic Chemistry), Center of Medical Biotechnology (ZMB) and Center for Nanointegration (CENIDE), University of Duisburg-Essen, Universitätsstraße 7, 45117, Essen, Germany.ORCID 0000-0001-7661-3231
Alexander HöingDepartment of Molecular Biology II, Center of Medical Biotechnology (ZMB), University of Duisburg-Essen, Universitätsstraße 2, 45141, Essen, Germany.
Johannes KochImaging Center Campus Essen (ICCE), Center of Medical Biotechnology (ZMB), University of Duisburg-Essen, Universitätsstraße 2, 45141, Essen, Germany.ORCID 0009-0002-3344-7303
Nina SchulzeImaging Center Campus Essen (ICCE), Center of Medical Biotechnology (ZMB), University of Duisburg-Essen, Universitätsstraße 2, 45141, Essen, Germany.ORCID 0009-0008-5503-6218
Elisabeth VerheggenFaculty of Chemistry (Organic Chemistry), Center of Medical Biotechnology (ZMB) and Center for Nanointegration (CENIDE), University of Duisburg-Essen, Universitätsstraße 7, 45117, Essen, Germany.
Felix C NiemeyerFaculty of Chemistry (Organic Chemistry), Center of Medical Biotechnology (ZMB) and Center for Nanointegration (CENIDE), University of Duisburg-Essen, Universitätsstraße 7, 45117, Essen, Germany.
Florian UteschilFaculty of Chemistry (Organic Chemistry), Center of Medical Biotechnology (ZMB) and Center for Nanointegration (CENIDE), University of Duisburg-Essen, Universitätsstraße 7, 45117, Essen, Germany.
Shirley K KnauerDepartment of Molecular Biology II, Center of Medical Biotechnology (ZMB), University of Duisburg-Essen, Universitätsstraße 2, 45141, Essen, Germany.
Jens VoskuhlFaculty of Chemistry (Organic Chemistry), Center of Medical Biotechnology (ZMB) and Center for Nanointegration (CENIDE), University of Duisburg-Essen, Universitätsstraße 7, 45117, Essen, Germany.ORCID 0000-0002-9612-2306

Funding

Deutsche Forschungsgemeinschaft 229838028Deutsche Forschungsgemeinschaft 397277702Deutsche Forschungsgemeinschaft CRC 1093
6 · The paper itself

Abstract

Two Cyanostyryl-guanidiniocarbonyl-pyrrole based amphiphiles are synthesized and examined in detail. In addition to achieving aggregation-induced emission from self-assembly, resulting in nanoparticles, it was found that the observed [2 + 2] photocycloaddition tunes the photophysical properties. The guanidiniocarbonyl-pyrrole component of these hybrid luminophores is shown to bind oxo-anions, such as pyrene-tetracarboxylate, as confirmed by fluorescence lifetime measurements. Moreover, both amphiphiles are used in bio-imaging experiments with HeLa cells, demonstrating effective cellular uptake.

Indexed as

Fluorescent DyesGuanidineGuanidinesPyrrolesSurface-Active AgentsDimerizationHeLa CellsHumansNanoparticlesOptical ImagingFluorescent DyesGuanidineGuanidinesPyrrolesSurface-Active Agentsaggregation‐induced‐emissionamphiphilesbio‐imagingself‐assemblystatic quenching

Identifiers

PMID40986285
PMCPMC12701296

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.